5-HO-MET

5-HO-MET, also known as 5-hydroxy-N-methyl-N-ethyltryptamine, is a psychedelic drug of the tryptamine and 5-hydroxytryptamine families related to bufotenin (5-HO-DMT).^[1] It is the derivative of bufotenin in which one of the two methyl groups at the amine has been extended to an ethyl group.^[1] The drug is also an analogue of methylethyltryptamine (MET), 4-HO-MET (metocin), and 5-MeO-MET.^[1] 5-HO-MET was reported as a novel designer drug in Canada in 2025.^[1] Its predicted log P is 1.6,^[2] relative to 1.2 in the case of bufotenin.^[3]

Other names5-OH-MET; 5-Hydroxy-MET; 5-Hydroxy-N-methyl-N-ethyltryptamine

Drug classSerotonergic psychedelic; Hallucinogen

ATC code

• None

PubChem CID

• 146478790

Quick facts Clinical data, Other names ...

5-HO-MET

Clinical data
Other names	5-OH-MET; 5-Hydroxy-MET; 5-Hydroxy-N-methyl-N-ethyltryptamine
Drug class	Serotonergic psychedelic; Hallucinogen
ATC code	None
Identifiers
IUPAC name 3-[2-[ethyl(methyl)amino]ethyl]-1H-indol-5-ol
PubChem CID	146478790
Chemical and physical data
Formula	C13H18N2O
Molar mass	218.300 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(C)CCC1=CNC2=C1C=C(C=C2)O
InChI InChI=1S/C13H18N2O/c1-3-15(2)7-6-10-9-14-13-5-4-11(16)8-12(10)13/h4-5,8-9,14,16H,3,6-7H2,1-2H3 Key:BQUBMTNAIITQAI-UHFFFAOYSA-N

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