5-MeO-MET
Chemical compound
From Wikipedia, the free encyclopedia
5-MeO-MET, also known as 5-methoxy-N-methyl-N-ethyltryptamine, is a serotonin receptor modulator, putative serotonergic psychedelic, and relatively rare designer drug of the tryptamine family related to psychedelic drugs like methylethyltryptamine (MET) and 5-MeO-DMT.[2][3][4][5][6]
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| Other names | 5-OMe-MET; 5-Methoxy-N-methyl-N-ethyltryptamine |
| Drug class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen |
| Pharmacokinetic data | |
| Onset of action | Unknown[1] |
| Duration of action | Unknown[1] |
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| Chemical and physical data | |
| Formula | C14H20N2O |
| Molar mass | 232.327 g·mol−1 |
| 3D model (JSmol) | |
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Use and effects
5-MeO-MET was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[1] Relatedly, its properties, such as dose and duration, and its effects were not described.[1] However, Nervewing later described the effects of 5-MeO-MET in an interview with Hamilton Morris and elsewhere.[7] They described 5-MeO-MET as producing no interesting psychological effects, as feeling like they had purely physically poisoned themselves, as feeling terrible and miserable, and as causing specific symptoms including nausea, chills, muscle aches, and almost vomiting, among others.[7]
Interactions
Pharmacology
Pharmacodynamics
Early studies found 5-MeO-MET to be more potent in animal behavioral tests than 5-MeO-DMT.[3][8] Subsequent studies confirmed that 5-MeO-MET interacts with serotonin receptors similarly to other psychedelic tryptamines.[9][10] A more modern study found that 5-MeO-MET is a potent serotonin 5-HT1A receptor ligand and serotonin 5-HT2A receptor agonist and produces the head-twitch response, a behavioral proxy of psychedelics, in rodents.[2][11] Its activities were of similar potency as 5-MeO-DMT.[2]
Chemistry
Analogues
Analogues of 5-MeO-MET include methylethyltryptamine (MET), 4-HO-MET (metocin), 4-AcO-MET (metacetin), 4-PrO-MET, 5-HO-MET, bretisilocin (5-fluoro-MET), 7F-5-MeO-MET, 5-MeO-DMT, 5-MeO-DET, 5-MeO-MPT, 5-MeO-EPT, 5-MeO-MALT, and 5-MeO-MiPT, among others.
History
Society and culture
Legal status
Canada
5-MeO-MET is not a controlled substance in Canada as of 2025.[14]
Sweden
5-MeO-MET is a controlled substance in Sweden.[15]
United States
5-MeO-MET is not an explicitly controlled substance in the United States.[16] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.