5-MeO-NiPT
Pharmaceutical compound
From Wikipedia, the free encyclopedia
5-MeO-NiPT, also known as 5-methoxy-N-isopropyltryptamine, is a psychedelic drug of the tryptamine family related to 5-MeO-DMT.[1][2][3]
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| Other names | 5-Methoxy-N-isopropyltryptamine |
| Drug class | Serotonin receptor agonist; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen |
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| Formula | C14H20N2O |
| Molar mass | 232.327 g·mol−1 |
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The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor.[1][2][3]
5-MeO-NiPT was encountered as a novel designer and recreational drug by 2014.[2][4]
Use and effects
5-MeO-NiPT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[5]
Interactions
Pharmacology
Pharmacodynamics
5-MeO-NiPT is a full agonist or near-full agonist of the serotonin 5-HT1A, 5-HT2A, 5-HT2B, and 5-HT2C receptors.[1][2][3] It is inactive as a serotonin releasing agent and is very weak as a serotonin reuptake inhibitor.[2][3]
Unlike most other N-monoalkylated tryptamines, 5-MeO-NiPT produces the head-twitch response (HTR), a behavioral proxy of psychedelic effects, in rodents, albeit relatively weakly.[1][2] It also produces hypolocomotion and hypothermia in rodents.[1][2] In combination with the serotonin 5-HT1A receptor antagonist WAY-100635 however, 5-MeO-NiPT instead produces hyperlocomotion.[1]
5-MeO-NiPT is an active metabolite of 5-MeO-MiPT and 5-MeO-DiPT.[1][6]
Chemistry
Analogues
Analogues of 5-MeO-NiPT include N-isopropyltryptamine (NiPT), 5-MeO-NMT, 5-MeO-NET, 5-MeO-DiPT, and 5-MeO-MiPT, among others.[5]
Society and culture
Legal status
Canada
5-MeO-NiPT is not a controlled substance in Canada.[7]
Sweden
5-MeO-NiPT is a controlled substance in Sweden.[8]
United States
5-MeO-NiPT is not an explicitly controlled substance in the United States.[9] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.