7,N,N-TMT
Chemical compound
From Wikipedia, the free encyclopedia
7,N,N-trimethyltryptamine (7,N,N-TMT or 7-TMT), also known as 7-methyl-DMT, is a serotonin receptor modulator and psychedelic drug of the tryptamine family related to dimethyltryptamine (DMT).[1][2][3] It was first described by 1978[1][4] and was encountered online as a novel designer drug in 2024.[5]
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| Other names | 7,N,N-Trimethyltryptamine; 7,N,N-TMT; 7-TMT; 7-Methyl-N,N-dimethyltryptamine; 7-Methyl-DMT; 7-Me-DMT |
| Drug class | Serotonin receptor modulator; Serotonergic psychedelic; Hallucinogen |
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| Formula | C13H18N2 |
| Molar mass | 202.301 g·mol−1 |
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Use and effects
7-Methyl-DMT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[6]
Interactions
Pharmacology
Pharmacodynamics
7-TMT acts as an agonist of 5-HT2 receptors.[1][2][3] In animal tests, both 7-TMT and its 5-methoxy derivative 5-MeO-7-TMT produced behavioural responses similar to those of psychedelic drugs such as DMT, but the larger 7-ethyl and 7-bromo derivatives of DMT did not produce psychedelic responses despite having higher 5-HT2 receptor affinity in vitro (cf. DOBU, DOAM).[7] 7-TMT also weakly inhibits reuptake of serotonin but with little effect on dopamine or noradrenaline reuptake.[4]
Chemistry
Synthesis
The chemical synthesis of 7,N,N-TMT has been described.[4]
Analogues
Analogues of 7-methyl-DMT include 7-methyltryptamine, dimethyltryptamine (DMT), 5-MeO-7-TMT (5-MeO-7,N,N-TMT), 7-MeO-DMT, 7-hydroxy-DMT, 7-methyl-AET, 7-MeO-DiPT, 7-MeO-MiPT, 7-chloro-AMT, 1-methyl-DMT, 2-methyl-DMT, 4-methyl-DMT, 5-methyl-DMT, and 6-methyl-DMT, among others.[6]
History
7,N,N-TMT was first described in the scientific literature by Richard Glennon and colleagues by 1978.[1][4] It was encountered online as a novel designer drug in 2024.[5]