ADL-5747

Chemical compound From Wikipedia, the free encyclopedia

ADL-5747 was a novel opioid analgesic drug, however its development was halted because it did not pass phase II trials.[1]

Quick facts Names, Identifiers ...
ADL-5747
Names
IUPAC name
N,N-diethyl-3-hydroxy-4-spiro[chromene-2,4'-piperidine]-4-ylbenzamide
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)17-9-10-18(21(27)15-17)20-16-24(11-13-25-14-12-24)29-22-8-6-5-7-19(20)22/h5-10,15-16,25,27H,3-4,11-14H2,1-2H3
    Key: ALGHKWSXJUQNJJ-UHFFFAOYSA-N
  • CCN(CC)C(=O)C1=CC(=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC=C42)O
Properties
C24H28N2O3
Molar mass 392.499 g·mol−1
Related compounds
Related compounds
 ADL-5859
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mechanism of action

ADL-5747 is an opioid analgesic, it works by activating opioid receptors. However, unlike "classical" opioids such as morphine, it is selective for the delta receptor.[2]

In tests done on mice, ADL-5747 was able to reduce pain in an efficient way. This compound does not seem to cause receptor internalization.[2]

References

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