AKAP6

A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.^[5][6][7]

AliasesAKAP6, ADAP100, ADAP6, AKAP100, PRKA6, mAKAP, A-kinase anchoring protein 6

External IDsOMIM: 604691; MGI: 3050566; HomoloGene: 3157; GeneCards: AKAP6; OMA:AKAP6 - orthologs

Chr.Chromosome 14 (human)^[1]

End32,837,684 bp^[1]

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AKAP6
Identifiers
Aliases	AKAP6, ADAP100, ADAP6, AKAP100, PRKA6, mAKAP, A-kinase anchoring protein 6
External IDs	OMIM: 604691; MGI: 3050566; HomoloGene: 3157; GeneCards: AKAP6; OMA:AKAP6 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 32,329,298 bp[1] End 32,837,684 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C1 Start 52,746,166 bp[2] End 53,202,382 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle prefrontal cortex muscle of thigh left ventricle ventricular zone Brodmann area 9 popliteal artery tibial arteries cingulate gyrus anterior cingulate cortex Top expressed in superior cervical ganglion trigeminal ganglion substantia nigra facial motor nucleus myocardium of ventricle extraocular muscle superior colliculus nucleus of stria terminalis Region I of hippocampus proper inferior colliculi More reference expression data BioGPS n/a
Gene ontology Molecular function protein-membrane adaptor activity transmembrane transporter binding adenylate cyclase binding protein kinase A binding protein binding molecular adaptor activity protein kinase A regulatory subunit binding Cellular component cytoplasm nuclear membrane nuclear envelope calcium channel complex membrane intercalated disc T-tubule junctional sarcoplasmic reticulum membrane sarcoplasmic reticulum perinuclear region of cytoplasm caveola nucleus Biological process protein targeting positive regulation of release of sequestered calcium ion into cytosol regulation of protein kinase A signaling cellular response to cytokine stimulus positive regulation of delayed rectifier potassium channel activity positive regulation of ryanodine-sensitive calcium-release channel activity positive regulation of calcineurin-NFAT signaling cascade positive regulation of cell growth positive regulation of potassium ion transmembrane transport action potential regulation of membrane repolarization positive regulation of cell growth involved in cardiac muscle cell development regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cAMP-mediated signaling cellular response to cAMP positive regulation of phosphoprotein phosphatase activity intracellular signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9472 238161 Ensembl ENSG00000151320 ENSMUSG00000061603 UniProt Q13023 n/a RefSeq (mRNA) NM_004274 NM_198111 RefSeq (protein) NP_004265 n/a Location (UCSC) Chr 14: 32.33 – 32.84 Mb Chr 12: 52.75 – 53.2 Mb PubMed search [3] [4]
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The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum.^[7]