AMY2A

Pancreatic alpha-amylase is an enzyme that in humans is encoded by the AMY2A gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesAMY2A, AMY2, AMY2B, PA, amylase, alpha 2A (pancreatic), amylase alpha 2A (pancreatic), amylase alpha 2A

External IDsOMIM: 104650; MGI: 88019; HomoloGene: 20179; GeneCards: AMY2A; OMA:AMY2A - orthologs

Chr.Chromosome 1 (human)^[1]

Quick facts Available structures, PDB ...

AMY2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1B2Y, 1BSI, 1CPU, 1HNY, 1KB3, 1KBB, 1KBK, 1KGU, 1KGW, 1KGX, 1U2Y, 1U30, 1U33, 1XCW, 1XCX, 1XD0, 1XD1, 1XGZ, 1XH0, 1XH1, 1XH2, 2CPU, 2QMK, 2QV4, 3BAI, 3BAJ, 3BAK, 3BAW, 3BAX, 3BAY, 3CPU, 3IJ7, 3IJ8, 3IJ9, 3OLD, 3OLE, 3OLG, 3OLI, 4GQQ, 4GQR, 4W93, 4X9Y, 5EMY
Identifiers
Aliases	AMY2A, AMY2, AMY2B, PA, amylase, alpha 2A (pancreatic), amylase alpha 2A (pancreatic), amylase alpha 2A
External IDs	OMIM: 104650; MGI: 88019; HomoloGene: 20179; GeneCards: AMY2A; OMA:AMY2A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.1 Start 103,617,427 bp[1] End 103,625,780 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F3|3 49.35 cM Start 113,349,359 bp[2] End 113,400,348 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans duodenum testicle nucleus accumbens fundus ectocervix putamen caudate nucleus right lobe of liver Top expressed in parotid gland lacrimal gland submandibular gland intercostal muscle left lobe of liver white adipose tissue neural layer of retina tunica adventitia of aorta subcutaneous adipose tissue lactiferous gland More reference expression data BioGPS n/a
Gene ontology Molecular function chloride ion binding calcium ion binding catalytic activity alpha-amylase activity hydrolase activity metal ion binding hydrolase activity, acting on glycosyl bonds cation binding Cellular component extracellular region extracellular exosome extracellular space Biological process carbohydrate catabolic process polysaccharide digestion metabolism carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 279 11722 Ensembl ENSG00000243480 ENSMUSG00000074264 UniProt P04746 P00687 RefSeq (mRNA) NM_000699 NM_001110505 NM_007446 RefSeq (protein) NP_000690 NP_001103975 NP_031472 Location (UCSC) Chr 1: 103.62 – 103.63 Mb Chr 3: 113.35 – 113.4 Mb PubMed search [3] [4]
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Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the pancreas.^[6]