ANAPC7

Protein-coding gene in humans From Wikipedia, the free encyclopedia

Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.[5] Multiple transcript variants encoding different isoforms have been found for this gene.

PDBOrtholog search: PDBe RCSB
AliasesANAPC7, APC7, anaphase promoting complex subunit 7, FERBON
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ANAPC7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANAPC7, APC7, anaphase promoting complex subunit 7, FERBON
External IDsOMIM: 606949; MGI: 1929711; HomoloGene: 10512; GeneCards: ANAPC7; OMA:ANAPC7 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019805

RefSeq (protein)

NP_001131136
NP_057322
NP_057322.2

NP_062779

Location (UCSC)Chr 12: 110.37 – 110.4 MbChr 5: 122.56 – 122.58 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a tetratricopeptide repeat containing component of the anaphase-promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.[5]

Interactions

ANAPC7 has been shown to interact with ANAPC1,[6][7] ANAPC4,[6] CDC27[6][8] and CDC20.[6][9]

References

Further reading

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