AP4B1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesAP4B1, BETA-4, CPSQ5, SPG47, adaptor related protein complex 4 beta 1 subunit, adaptor related protein complex 4 subunit beta 1
Quick facts Available structures, PDB ...
AP4B1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAP4B1, BETA-4, CPSQ5, SPG47, adaptor related protein complex 4 beta 1 subunit, adaptor related protein complex 4 subunit beta 1
External IDsOMIM: 607245; MGI: 1337130; HomoloGene: 38203; GeneCards: AP4B1; OMA:AP4B1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001253852
NM_001253853
NM_001308312
NM_006594

NM_001163552
NM_001163553
NM_026193

RefSeq (protein)

NP_001240781
NP_001240782
NP_001295241
NP_006585

NP_001157024
NP_001157025
NP_080469

Location (UCSC)Chr 1: 113.89 – 113.91 MbChr 3: 103.72 – 103.73 Mb
PubMed search[3][4]
Wikidata
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Function

The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsilon-4 (AP4E1), a medium chain, mu-4 (AP4M1), and a small chain, sigma-4 (AP4S1)[6]

Interactions

AP4B1 has been shown to interact with AP4M1.[7]

Clinical relevance

AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.[8][9]

References

Further reading

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