Acetyl-CoA C-acetyltransferase
Class of enzymes
From Wikipedia, the free encyclopedia
Acetyl-CoA C-acetyltransferase (EC 2.3.1.9) is an enzyme that catalyzes the chemical reaction
| Acetyl-CoA C-acetyltransferase | |||||||||
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 Crystallographic structure of the tetrameric acetoacetyl-CoA thiolase (EC:2.3.1.9) from the Gram-negative bacterium Z. ramigera.[1] | |||||||||
| Identifiers | |||||||||
| EC no. | 2.3.1.9 | ||||||||
| CAS no. | 9027-46-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme has one substrate, acetyl-CoA, and converts two molecules of this into acetoacetyl-CoA and coenzyme A.[2][3]
Acetyl-CoA C-acetyltransferase has a cysteine at its active site, and is a transferase in the group of acyltransferases which transfer groups other than aminoacyl groups. Its systematic name is acetyl-CoA:acetyl-CoA C-acetyltransferase. Other names in common use include acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, and thiolase II. This enzyme participates in many metabolic pathways including fatty acid metabolism, synthesis and degradation of ketone bodies, valine, leucine and isoleucine degradation, lysine degradation, tryptophan metabolism, pyruvate metabolism, propanoate metabolism, and butanoate metabolism.[4]
Isozymes
Human genes encoding acetyl-CoA C-acetyltransferases include:
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