Adapter molecule crk
Protein found in humans
From Wikipedia, the free encyclopedia
Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene.[5]
The CRK protein participates in the Reelin signaling cascade downstream of DAB1.[6][7]
Function
Adapter molecule crk is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. This protein has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.[8]
Crk together with CrkL participates in the Reelin signaling cascade downstream of DAB1.[6][7]
v-Crk, a transforming oncoprotein from avian sarcoma viruses, is a fusion of viral "gag" protein with the SH2 and SH3 domains of cellular Crk.[9] The name Crk is from "CT10 Regulator of Kinase" where CT10 is the avian virus from which was isolated a protein, lacking kinase domains, but capable of stimulating phosphorylation of tyrosines in cells.[10]
Crk should not be confused with Src, which also has cellular (c-Src) and viral (v-Src) forms and is involved in some of the same signaling pathways but is a protein tyrosine-kinase.
Interactions
CRK (gene) has been shown to interact with:
- BCAR1,[11][12][13][14][15][16][17][18][19][excessive citations]
- Cbl gene,[20][21]
- Dock180,[22][13][14][23][24]
- EPS15,[25]
- Epidermal growth factor receptor,[26][27]
- Grb2,[28][22][29]
- IRS4,[30][31]
- MAP4K1,[32][33][34]
- MAPK8,[35]
- NEDD9,[36][37]
- PDGFRA,[38][39]
- PDGFRB,[38]
- PTK2,[13][16]
- Paxillin[16][40]
- RAPGEF1,[41]
- RICS,[42][43]
- SH3KBP1,[44] and
- SOS1.[29]
See also
- CrkL, "Crk-like" protein