Adenosine reuptake inhibitor
Drug class
From Wikipedia, the free encyclopedia
An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters (ENTs).[1][2][3] This in turn leads to increased extracellular concentrations of adenosine and therefore an increase in adenosinergic neurotransmission.
List of AdoRIs
- Benzodiazepines[4]
- Calcium channel blockers[5]
- Carisoprodol[6][7][8]
- Cilostazol[9]
- Cyclobenzaprine[10][11]
- Dilazep[1]
- Dipyridamole[1][12]
- Estradiol[13]
- Ethanol[14]
- Hexobendine[15]
- Hydroxyzine[16]
- Inosine[17]
- KF24345[18]
- Meprobamate[6][7]
- Nitrobenzylthioguanosine[19]
- Nitrobenzylthioinosine[1][20]
- Papaverine[21]
- Pentoxifylline[22]
- Phenothiazines[10][23]
- Phenytoin[24]
- Progesterone[13]
- Propentofylline[25]
- Puromycin[10]
- R75231[26]
- RE 102 BS[27]
- Soluflazine[28][29]
- Toyocamycin[10]
- Tracazolate[16]
- Tricyclic antidepressants[10][11]
See also
References
- SenGupta DJ, Unadkat JD (2004). "Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep". Biochem Pharmacol. 67 (3): 453–458. doi:10.1016/j.bcp.2003.09.018. PMID 15037197.
- Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1". Biochem J. 380 (1): 131–137. doi:10.1042/BJ20031880. PMC 1224139. PMID 14759222.
- Chaudary N, Naydenova Z, Shuralyova I, Coe IR (2004). "The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1". J Pharmacol Exp Ther. 310 (3): 1190–1198. doi:10.1124/jpet.104.067157. PMID 15131243. S2CID 21804556.
- York MJ, Davies LP (1982). "The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain". Can J Physiol Pharmacol. 60 (3): 302–307. doi:10.1139/y82-041. PMID 6280826.
- Goldfrank LR, Neal Flomenbaum, Mary Ann Howland, Robert S. (2006). Goldfrank's toxicologic emergencies. p. 243.
- Phillis JW, Delong RE (1984). "A purinergic component in the central actions of meprobamate". Eur J Pharmacol. 101 (3–4): 295–297. doi:10.1016/0014-2999(84)90174-2. PMID 6468504.
- DeLong RE, Phillis JW, Barraco RA (1985). "A possible role of endogenous adenosine in the sedative action of meprobamate". Eur J Pharmacol. 118 (3): 359–362. doi:10.1016/0014-2999(85)90149-9. PMID 4085561.
- Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH (2009). "[Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies". J Pharmacol Exp Ther. 329 (2): 827–837. doi:10.1124/jpet.109.151142. PMC 2672873. PMID 19244096.
- Wang S, Cone J, Fong M, Yoshitake M, Kambayashi Ji, Liu Y (2001). "Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication". J Cardiovasc Pharmacol. 38 (5): 775–783. doi:10.1097/00005344-200111000-00014. PMID 11602824.
- Phillis JW, Wu PH (1982). "The effect of various centrally active drugs on adenosine uptake by the central nervous system". Comp Biochem Physiol C. 72 (2): 179–187. doi:10.1016/0306-4492(82)90082-X. PMID 6128137.
- Phillis J.W. (1984). "Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants". Br J Pharmacol. 83 (2): 567–575. doi:10.1111/j.1476-5381.1984.tb16521.x. PMC 1987110. PMID 6487906.
- Stein MB, Black B, Brown TM, Uhde TW (1993). "Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders". Biol Psychiatry. 33 (8–9): 647–650. doi:10.1016/0006-3223(93)90105-M. PMID 8329495. S2CID 54364716.
- Phillis JW, Bender AS, Marszalec W (1985). "Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons". Gen Pharmacol. 16 (6): 609–612. doi:10.1016/0306-3623(85)90151-x. PMID 2935451.
- Allen-Gipson DS, Jarrell JC, Bailey KL, Robinson JE, Kharbanda KK, Sisson JH, Wyatt TA (2009). "Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells". Alcohol Clin Exp Res. 33 (5): 791–8. doi:10.1111/j.1530-0277.2009.00897.x. PMC 2940831. PMID 19298329.
- Verma A, Houston M, Marangos PJ (1985). "Solubilization of an adenosine uptake site in brain". J Neurochem. 45 (2): 596–603. doi:10.1111/j.1471-4159.1985.tb04028.x. PMID 2989430. S2CID 42431981.
- Phillis JW, Wu PH, Coffin VL (1983). "Inhibition of adenosine uptake into rat brain synaptosomes by prostaglandins, benzodiazepines and other centrally active compounds". Gen Pharmacol. 14 (5): 475–479. doi:10.1016/0306-3623(83)90106-4. PMID 6416920.
- Ngai AC, Monsen MR, Ibayashi S, Ko KR, Winn HR (1989). "Effect of inosine on pial arterioles: potentiation of adenosine-induced vasodilation". Am J Physiol. 256 (3 (Pt2)): H603–H606. doi:10.1152/ajpheart.1989.256.3.H603. PMID 2923227.
- Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, Nishikawa S, Karasawa A, Kusaka H (2002). "KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice". Eur J Pharmacol. 454 (1): 85–93. doi:10.1016/S0014-2999(02)02476-7. PMID 12409009.
- Shi D, Daly JW (1999). "Chronic effects of xanthines on levels of central receptors in mice". Cell Mol Neurobiol. 19 (6): 719–732. doi:10.1023/A:1006901005925. PMC 11545639. PMID 10456233. S2CID 10644334.
- Phillis J.W. (1985). "Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons". Gen Pharmacol. 16 (1): 19–24. doi:10.1016/0306-3623(85)90264-2. PMID 2984085.
- Andiné P, Rudolphi KA, Fredholm BB, Hagberg H (1990). "Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia". Br J Pharmacol. 100 (4): 814–818. doi:10.1111/j.1476-5381.1990.tb14097.x. PMC 1917600. PMID 2207501.
- Bauman LA, Mahle CD, Boissard CG, Gribkoff VK (1992). "Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices". J Neurophysiol. 68 (2): 629–638. doi:10.1152/jn.1992.68.2.629. PMID 1388201.
Related Articles
~