Angiofibroma of soft tissue
From Wikipedia, the free encyclopedia
| Angiofibroma of soft tissue | |
|---|---|
| Specialty | Dermatology, General surgery, Pathology |
| Types | Benign |
| Causes | unknown |
| Treatment | Surgical removal |
| Prognosis | Good |
| Frequency | Rare |
Angiofibroma of soft tissue (AFST), also termed angiofibroma, not otherwise specified, is a recently recognized and rare disorder that was classified in the category of benign fibroblastic and myofibroblastic tumors by the World Health Organization in 2020.[1] An AFST tumor is a neoplasm (i.e. growth of tissue that is not coordinated with the normal surrounding tissue and persists in growing even if the original trigger for growth is removed) that was first described by A. Mariño-Enríquez and C.D. Fletcher in 2012.[2]
AFST tumors typically occur in a leg but can occur in other locations; they develop in older children and adults including elderly individuals. AFSTs are slow-growing, often painless tumors composed primarily of spindle-shaped cells and a prominent vascular network. The spindle-shaped cells are benign tumor cells that in almost all cases have chromosome abnormalities that are thought to contribute to their abnormal development and/or growth.[3]
AFST tumors are commonly treated by surgical excision although in uncommon cases they recur at the site of their removal and require further surgical treatment.[2] They do not metastasize to distant tissues and overall have a good prognosis.[4]
AFST tumors commonly present as slowly growing, painless, deep-seated lumps in individuals aged 6 to 86 years old (median age 47–50 years in different studies).[4] The tumors are most common in the lower extremities but uncommonly occur in the back, chest wall, iliac crest, groin and nearby lower lateral abdominal region,[4] abdominal cavity, pelvic cavity,[5] breast,[3] cheek, temporal region of the head and, in a report on 24 AFST cases done in Shanghai, the upper limb in 3 cases and, in 1 case each, the retroperitoneum and liver.[6] The tumors' longest diameters have ranged from 1.2 to 10 cm (mean: 5.1 cm)[4] and 0.8 to 14 cm (mean: 4.6 cm)[6] in two different studies.
Pathology
Grossly, AFST tumors, when visible on skin, are located in the skin's subcutaneous tissue or the fascia layer below the subcutaneous tissue.[3] They may be infiltrating deeper into these tissues[4] and/or into nearby large joints.[3] Regardless of location, however, most of these tumors are well-circumscribed.[5]
Histopathological microscopic analyses of hematoxylin and eosin-stained AFST tissues generally reveal bland appearing spindle-shaped cells and a prominent small, thin-walled blood vessels network in a background of alternating myxoid connective tissue areas and more highly cellular collagen fiber-rich connective tissue areas. (Myxoid indicates areas that appear more blue or purple than normal due to their high uptake of the hematoxylin stain.) Typically, these tumors appear well-circumscribed but some cases show them infiltrating into adjacent normal adipose tissues, connective tissues, skeletal muscles, and/or joints.[4] Immunohistochemistry analyses (i.e. identifying specific proteins in cells using antibodies that bind to these proteins) of AFST tissues detect cells bearing estrogen receptor, CD163 and NCOA2 proteins in 100% of cases; MUC1 (also termed EMA) protein in 46% of cases; desmin protein in 22% of cases; ACTA2 (also termed α-SMA), CD34, and STAT6 proteins in 10% or fewer cases, and S100 and cytokeratin proteins in no cases.
Chromosome and gene abnormalities
In 60-80% of cases, the cells in AFST tumors express the AHRR-NCOA2 fusion gene. A fusion gene is a hybrid gene formed from two previously independent genes as a result of a translocation, interstitial deletion, or chromosomal inversion.[5] The AHRR gene (i.e. gene for the aryl hydrocarbon receptor repressor protein) is located at band 15.33 on the short (or "p") arm of chromosome 5 (cite designation: 5p15.33);[7] The NCOA2 gene (i.e. gene for the nuclear receptor coactivator 2 protein) is located at band 13.3 on the long (or "q") arm of chromosome 8 (cite designation: 8q13.3).[8] A translocation between these two chromosomes creates the AHRR-NCOA2 fusion gene (fusion gene designation: t(5;8)(q15;q13)).[9] AHRR is a tumor suppressor gene that when fused to other genes is found in the cells of, and thought to promote, various leukemias and neoplasms. It is thought to similarly promote the development and/or progression of AFST tumors.[4] While most commonly associated with the AHRR-NCOA2 fusion gene, rare AFST tumor cases have also been shown to be associated with GAB1-ABL1, GTF2I-NCOA2, NCOA2-ETV4, ETV4-AHRR,[4] and NAB2-STAT6[4] fusion genes.