Anthocyanidin reductase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, anthocyanidin reductase (EC 1.3.1.77) is an enzyme that catalyzes the general chemical reaction
- an anthocyanidin + 2 NAD(P)H + H+ a flavan-3-ol + 2 NAD(P)+
| Anthocyanidin reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.3.1.77 | ||||||||
| CAS no. | 93389-48-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
For example, the enzyme converts the anthocyanidin cyanidin to the flavanol (–)-epicatechin by reduction:
-Epicatechin.svg)
In this case, the three substrates of this enzyme are cyanidin, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. It converts them to (–)-epicatechin and oxidised NADP+.[1][2] The enzyme from the legume Medicago truncatula can use nicotinamide adenine dinucleotide as an alternative cofactor.[3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is flavan-3-ol:NAD(P)+ oxidoreductase. Other names in common use include AtANR, and MtANR. This enzyme participates in flavonoid biosynthesis.
