BD1067

BD1067
Identifiers
	IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-N-ethyl-1-pyrrolidineethanamine;
CAS Number	138356-12-4;
PubChem CID	9796923;
ChemSpider	7972689;
UNII	B735YEI65V;
CompTox Dashboard (EPA)	DTXSID601030389 ;
Chemical and physical data
Formula	C16H24Cl2N2
Molar mass	315.28 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN(CCC1=CC(=C(C=C1)Cl)Cl)CCN2CCCC2;
	InChI InChI=1S/C16H24Cl2N2/c1-2-19(11-12-20-8-3-4-9-20)10-7-14-5-6-15(17)16(18)13-14/h5-6,13H,2-4,7-12H2,1H3; Key:NMEAEGORKFOIDR-UHFFFAOYSA-N;

BD1067 or N-[2-(3,4-dichlorophenyl)ethyl]-N-ethyl-1-pyrrolidineethanamine is a selective sigma receptor antagonist, with a reported binding affinity of K_i = 2 ± 0.5 nM for the sigma-1 receptor and greater than 19 times selectivity over the sigma-2 receptor.^[1]

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Like other sigma receptor antagonists, pretreating Swiss Webster mice with BD1067 significantly attenuates the behavioral toxicity of cocaine.^[1]

See also

Identifiers

IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-N-ethyl-1-pyrrolidineethanamine
CAS Number	138356-12-4
PubChem CID	9796923
ChemSpider	7972689
UNII	B735YEI65V
CompTox Dashboard (EPA)	DTXSID601030389
Chemical and physical data
Formula	C₁₆H₂₄Cl₂N₂
Molar mass	315.28 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CCN(CCC1=CC(=C(C=C1)Cl)Cl)CCN2CCCC2
InChI InChI=1S/C16H24Cl2N2/c1-2-19(11-12-20-8-3-4-9-20)10-7-14-5-6-15(17)16(18)13-14/h5-6,13H,2-4,7-12H2,1H3 Key:NMEAEGORKFOIDR-UHFFFAOYSA-N