BRICHOS family
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| BRICHOS domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| Symbol | BRICHOS | ||||||||
| Pfam | PF04089 | ||||||||
| InterPro | IPR007084 | ||||||||
| PROSITE | PDOC50869 | ||||||||
| CATH | 2yadA00 | ||||||||
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The BRICHOS family consists of a variety of proteins linked to major diseases, each containing a 100 amino acid BRICHOS domain that is thought to have a chaperone function.[1][2] These include BRI2, which is related to familial British and Danish dementia (FBD and FDD); Chondromodulin-I, related to chondrosarcoma; CA11, related to stomach cancer; and surfactant protein C (SP-C), related to respiratory distress syndrome (RDS).