Becaplermin
Pharmaceutical drug
From Wikipedia, the free encyclopedia
Becaplermin, sold under the brand name Regranex, is a cicatrizant, available as a topical gel. Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity diabetic neuropathic ulcers.[1] It is also known as "platelet-derived growth factor BB".[1]
| Clinical data | |
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| Trade names | Regranex |
| AHFS/Drugs.com | Consumer Drug Information |
| MedlinePlus | a699049 |
| Routes of administration | Topical |
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Medical uses
Becaplermin is used for the treatment of diabetic foot ulcers.[2] Studies of becaplermin showed that when used with good wound care, complete healing significantly increased and the ulcers healed on average 6 weeks faster.[3] Pharmacoeconomic studies reinforce the cost effectiveness of becaplermin as an adjunct to good wound care.[4]
The amount of becaplermin to be applied will vary depending upon the size of the ulcer area. Becaplermin should be stored in the refrigerator.[1] Analysis of healing human wounds showed that PDGF-BB induces fibroblast proliferation and differentiation and was found to increase healing in patients with decreased healing capacity, such as people living with diabetes.[5]
Contraindications
Becaplermin must not be used at the site of a skin cancer.[6]
Adverse effects
The most common side effects in clinical studies were erythematous rashes.[6]
