Buclizine

Buclizine is an antihistamine and anticholinergic of the diphenylmethylpiperazine group. It is considered to be an antiemetic, similar to meclizine.^[1]

AHFS/Drugs.comMicromedex Detailed Consumer Information

ATC code

• R06AE01 (WHO)

CAS Number

• 82-95-1 ^Y

PubChem CID

• 6729

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Buclizine

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	R06AE01 (WHO)
Identifiers
IUPAC name (RS)-1-[(4-chlorophenyl)- phenyl-methyl]-4- [(4-tert-butylphenyl) methyl] piperazine
CAS Number	82-95-1 Y
PubChem CID	6729
IUPHAR/BPS	7134
DrugBank	DB00354 Y
ChemSpider	6473 Y
UNII	0C94V6X681
ChEBI	CHEBI:3205 Y
ChEMBL	ChEMBL1201271 N
CompTox Dashboard (EPA)	DTXSID0022694
ECHA InfoCard	100.001.317
Chemical and physical data
Formula	C28H33ClN2
Molar mass	433.04 g·mol−1
3D model (JSmol)	Interactive image
Chirality	Racemic mixture
SMILES Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)Cc4ccc(cc4)C(C)(C)C
InChI InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3 Y Key:MOYGZHXDRJNJEP-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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In the United Kingdom, buclizine is one of three drugs contained in Migraleve tablets, marketed by McNeil Healthcare for migraines.^[2]