C14orf93

c14orf93 is located on the short arm of chromosome 14 (14q11.2).^[5] c14orf93’s accession number is 021944, and its aliases are FLJ12154 and LOC60686. The gene has 2430 bp and 7 exons.^[6]

The c14orf93 protein has 9 isoforms.^[7] The most common and largest isoform has 538 AAs,^[8] a molecular weight of 58.7 kdal,^[9] and a theoretical isoelectric point of 5.7.^[10] This protein is globular with a conserved C-terminus, a mixed charge cluster from 371 to 399, and a high scoring uncharged segment from 28 to 58.^[9] SDSC PELE consensus data predicts 15 alpha helixes and 8 beta strands.^[9]

Post-translational modifications to c14orf93 include phosphorylation, N-acetylation, and sumoylation. Serine phosphorylation sites are predicted at 23 residues, threonine at 6 residues, and tyrosine at 2 residues.^[11] There are two experimentally confirmed serine phosphorylation sites at residues 285 and 428,^[6] which may serve as sites of activation or deactivation. N-acetylation is predicated at the second residue; this modification affects stability and localization.^[12] There are 6 motifs with high probability of sumoylation.^[13] SUMO (small ubiquitin-like modifiers) are small proteins like ubiquitin that start a cascade involved in protein stability, nuclear-cytosolic transport, and transcriptional regulation.

PSORTII data predicts that c14orf93 is localized to the nucleus.^[14] There is a nuclear localization signal at residues 298-301. There are also two peroxisomal targeting signals at residues 451-459 and 479-487.

c14orf93 is expressed 2.7 times higher than the average gene across all tissues.^[7] It is expressed relatively highly in all tissues except for nervous tissue.^[15] There is markedly higher expression seen in T cells, and there is a slightly higher expression pattern shown in other immune tissues such as bone marrow, spleen, and lymph nodes.