C1D
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Nuclear nucleic acid-binding protein C1D is a protein that in humans is encoded by the C1D gene.[5][6][7][8][9][10] The C1D protein is encoded by a DNA binding gene traced in the nucleus.[11] Protein C1D has a chromosomal location of 2p14.[12] C1D has a family of proteins consisting of C1D homologues which may include Sas10 domains.[13] C1D is thought to bind to RNA and DNA where it may be involved in mechanisms of DNA repair.[13] Protein C1D is ubiquitously expressed in different human tissues.[14]
| C1D | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | C1D, LRP1, SUN-CoR, SUNCOR, hRrp47, C1D nuclear receptor corepressor | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 606997; MGI: 1927354; HomoloGene: 4619; GeneCards: C1D; OMA:C1D - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
Despite inducing denaturing conditions, C1D shows high-affinity binding to DNA.[13] C1D has demonstrated capability to bind to DNA in DNA repair pathways.[13]
The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Protein C1D may have a protective effect against relation to the TRAX/Translin complex formation of DNA.[13] Several alternatively spliced transcript variants of this gene have been described, but the full length nature of some of these variants has not been determined.[10]
