C5a receptor

C5AR1
Identifiers
Aliases	C5AR1, C5A, C5AR, C5R1, CD88, complement component 5a receptor 1, C5a receptor, complement C5a receptor 1
External IDs	OMIM: 113995; MGI: 88232; HomoloGene: 20413; GeneCards: C5AR1; OMA:C5AR1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	47,322,066 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	15,993,465 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; bone marrow; ; granulocyte; ; bone marrow cell; ; pituitary gland; ; right lung; ; anterior pituitary; ; periodontal fiber; ; upper lobe of left lung;
	Top expressed in
	granulocyte; ; aortic valve; ; stroma of bone marrow; ; ascending aorta; ; blood; ; tibiofemoral joint; ; lumbar spinal ganglion; ; ankle; ; choroid plexus of fourth ventricle; ; right lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	complement component C5a binding; signal transducer activity; complement receptor activity; complement component C5a receptor activity; G protein-coupled receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; apical part of cell; integral component of plasma membrane; cell surface; basolateral plasma membrane; cytoplasmic vesicle; secretory granule membrane;
Biological process	negative regulation of neuron apoptotic process; positive regulation of epithelial cell proliferation; mRNA transcription by RNA polymerase II; activation of phospholipase C activity; neutrophil chemotaxis; positive regulation of angiogenesis; chemotaxis; cellular defense response; response to lipopolysaccharide; animal organ regeneration; immune response; response to peptidoglycan; positive regulation of ERK1 and ERK2 cascade; positive regulation of neutrophil chemotaxis; complement receptor mediated signaling pathway; sensory perception of chemical stimulus; positive regulation of vascular endothelial growth factor production; cell proliferation in hindbrain; positive regulation of macrophage chemotaxis; signal transduction; defense response to Gram-positive bacterium; apoptotic process; regulation of complement activation; inflammatory response; phospholipase C-activating G protein-coupled receptor signaling pathway; neutrophil degranulation; leukocyte migration; cell chemotaxis; positive regulation of cytosolic calcium ion concentration; G protein-coupled receptor signaling pathway; complement component C5a signaling pathway; cognition; regulation of astrocyte activation; presynapse organization; regulation of amyloid-beta clearance; regulation of tau-protein kinase activity; regulation of microglial cell activation;
	Sources:Amigo / QuickGO
Orthologs
	728
	12273
	ENSG00000197405
	ENSMUSG00000049130
	P21730
	P30993
	NM_001736
	NM_001173550; NM_007577
	NP_001727
	NP_001167021; NP_031603
	Wikidata
View/Edit Human	View/Edit Mouse

The C5a receptor also known as complement component 5a receptor 1 (C5AR1) or CD88 (Cluster of Differentiation 88) is a G protein-coupled receptor for C5a. It functions as a complement receptor.^[5] C5a receptor 1 modulates inflammatory responses, obesity, development and cancers.^[6]^[7]^[8] From a signaling transduction perspective, C5a receptor 1 activation is implicated in β-arrestin2 recruitment via Rab5a,^[9] coupling of Gαi proteins,^[10] ERK1/2 phosphorylation,^[11] calcium mobilization and Rho activation^[12] leading to downstream functions, such as secretion of cytokines, chemotaxis, and phagocytosis.