C9orf25
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| FAM219A | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | FAM219A, C9orf25, bA573M23.5, family with sequence similarity 219 member A | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 1919151; HomoloGene: 51830; GeneCards: FAM219A; OMA:FAM219A - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Chromosome 9 open reading frame 25 (C9orf25) is a domain that encodes the FAM219A gene.[5] The terms FAM219A and C9orf25 are aliases and can be used interchangeably. The function of this gene is not yet completely understood.
Location
In humans, C9orf25 is located at the 9p13.3 position on chromosome 9.[6] The gene is encoded on the sense strand (-) spanning the chromosomal locus from base pair 34,502,909 to 34,398,027.[5][7] The span of the gene is 104,882 base pairs[8][9][10][11][12][13][14]
Transcript variants
In humans there are 8 main transcript variants of the FAM219A gene.[7] All of these transcripts have varying lengths and splice sites with transcript variant 1 being the longest and most abundant.[5][7] Only four of these transcripts encode for a protein product.[15]
Homology
Orthologs
The C9orf25 gene has orthologs in a wide variety of Eukaryotic organisms, including invertebrates. This gene has not been found in plants, fungi or protists.[17] C9orf25 is a slowly evolving gene.[16] It is also highly conserved throughout all of its known orthologs.
Paralogs
C9orf25 has a paralog FAM219B which is located on the long arm of chromosome 9 and is 198 amino acids long.[18] The C9orf25 and FAM219B genes duplicated and diverged between 684 and 797 million years ago.
