CD300A

CMRF35-like molecule 8 is a protein encode by CD300A (Cluster of Differentiation 300A) gene.^[4]

PDBOrtholog search: PDBe RCSB

AliasesCD300A, CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, CD300a molecule

External IDsOMIM: 606790; MGI: 2443411; HomoloGene: 48514; GeneCards: CD300A; OMA:CD300A - orthologs

Chr.Chromosome 17 (human)^[1]

Quick facts Available structures, PDB ...

CD300A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q87
Identifiers
Aliases	CD300A, CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, CD300a molecule
External IDs	OMIM: 606790; MGI: 2443411; HomoloGene: 48514; GeneCards: CD300A; OMA:CD300A - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,466,399 bp[1] End 74,484,794 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood monocyte spleen bone marrow bone marrow cell amniotic fluid appendix periodontal fiber lymph node n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity phosphatidylethanolamine binding phosphatidylserine binding protein binding Cellular component integral component of membrane extracellular exosome membrane plasma membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process regulation of T cell receptor signaling pathway immune system process negative regulation of eosinophil migration positive regulation of phosphoprotein phosphatase activity negative regulation of neutrophil activation negative regulation of eosinophil activation regulation of immune response negative regulation of fibroblast proliferation negative regulation of MAP kinase activity negative regulation of mast cell degranulation negative regulation of mast cell activation involved in immune response cell adhesion negative regulation of NK T cell activation negative regulation of B cell receptor signaling pathway negative regulation of activation of Janus kinase activity negative regulation of phagocytosis, engulfment negative regulation of B cell proliferation signal transduction negative regulation of MyD88-dependent toll-like receptor signaling pathway neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11314 217303 Ensembl ENSG00000167851 n/a UniProt Q9UGN4 Q6SJQ0 RefSeq (mRNA) NM_001256841 NM_007261 NM_001330456 NM_001330457 NM_170758 NM_001347654 NM_001359812 RefSeq (protein) NP_001243770 NP_001317385 NP_001317386 NP_009192 NP_001334583 NP_739564 NP_001346741 Location (UCSC) Chr 17: 74.47 – 74.48 Mb n/a PubMed search [2] [3]
Wikidata
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The CD300C, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CD300A is recognized by the same antibody and is distinct from CD300C (Green et al., 1998).[supplied by OMIM]^[4]