CNOT1

CCR4-NOT transcription complex subunit 1 is a protein that in humans is encoded by the CNOT1 gene.^[5][6]

AliasesCNOT1, CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12, VIBOS

External IDsOMIM: 604917; MGI: 2442402; GeneCards: CNOT1

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 16 (human)^[1]

Quick facts Identifiers, Aliases ...

CNOT1
Identifiers
Aliases	CNOT1, CDC39, NOT1, NOT1H, AD-005, CCR4-NOT transcription complex subunit 1, HPE12, VIBOS
External IDs	OMIM: 604917; MGI: 2442402; GeneCards: CNOT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4C0D, 4CQO, 4CRV, 4CRW, 4CT4, 4CT6, 4CT7, 4GMJ, 4GML, 4J8S, 5ANR, 5FU6, 5FU7
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 58,519,951 bp[1] End 58,629,885 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 D1 Start 96,446,079 bp[2] End 96,534,092 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad left testis right testis ventricular zone ganglionic eminence mucosa of transverse colon skin of abdomen skin of leg granulocyte epithelium of colon Top expressed in tail of embryo genital tubercle spermatocyte ventricular zone spermatid yolk sac neural layer of retina zygote granulocyte morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(A)-specific ribonuclease activity protein domain specific binding protein binding retinoic acid receptor binding armadillo repeat domain binding molecular adaptor activity estrogen receptor binding RNA binding Cellular component membrane CCR4-NOT complex peroxisomal membrane P-body CCR4-NOT core complex nucleus extracellular space cytoplasm cytosol Biological process nuclear-transcribed mRNA poly(A) tail shortening negative regulation of translation positive regulation of nuclear-transcribed mRNA poly(A) tail shortening regulation of transcription, DNA-templated negative regulation of retinoic acid receptor signaling pathway regulation of stem cell population maintenance negative regulation of transcription by RNA polymerase II positive regulation of mRNA catabolic process transcription, DNA-templated multicellular organism development positive regulation of cytoplasmic mRNA processing body assembly positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay gene silencing by miRNA gene silencing negative regulation of intracellular estrogen receptor signaling pathway regulation of translation RNA phosphodiester bond hydrolysis, exonucleolytic DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 23019 234594 Ensembl ENSG00000125107 ENSMUSG00000036550 UniProt A5YKK6 H3BNB1 Q6ZQ08 RefSeq (mRNA) NM_001265612 NM_016284 NM_206999 NM_001205226 NM_153164 NM_178078 NM_001372351 NM_001372353 RefSeq (protein) NP_001252541 NP_057368 NP_996882 NP_001192155 NP_694804 NP_835179 NP_001359280 NP_001359282 Location (UCSC) Chr 16: 58.52 – 58.63 Mb Chr 8: 96.45 – 96.53 Mb PubMed search [3] [4]
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It is a part of the CCR4-Not complex, which deadenylates mRNAs.^[7] CNOT1 acts as a scaffold protein, binding other subunits of the complex.^[8][9][10]