CPM-LAD

Pharmaceutical compound From Wikipedia, the free encyclopedia

CPM-LAD, or CYPM-LAD, also known as 6-(cyclopropylmethyl)-6-nor-LSD, is a serotonin receptor modulator and putative psychedelic drug of the lysergamide family.[1][2][3][4] It is the analogue of LSD in which the methyl group at the 6 position has been replaced with a cyclopropylmethyl group.[1][2][3]

Other namesCPMLAD; CYPM-LAD; CYPMLAD; 6-(Cyclopropylmethyl)-6-nor-LSD; N(6)-Cyclopropylmethyl-norLSD;
Drug classSerotonin receptor modulator; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
PubChem CID
Quick facts Clinical data, Other names ...
CPM-LAD
Clinical data
Other namesCPMLAD; CYPM-LAD; CYPMLAD; 6-(Cyclopropylmethyl)-6-nor-LSD; N(6)-Cyclopropylmethyl-norLSD;
Drug classSerotonin receptor modulator; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • (6aR,9R)-7-(cyclopropylmethyl)-N,N-diethyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide
PubChem CID
Chemical and physical data
FormulaC23H29N3O
Molar mass363.505 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)CC5CC5
  • InChI=1S/C23H29N3O/c1-3-25(4-2)23(27)17-10-19-18-6-5-7-20-22(18)16(12-24-20)11-21(19)26(14-17)13-15-8-9-15/h5-7,10,12,15,17,21,24H,3-4,8-9,11,13-14H2,1-2H3/t17-,21-/m1/s1
  • Key:XTKDRKBVDJFYNW-DYESRHJHSA-N
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Use and effects

Unlike related lysergamides, CPM-LAD was not mentioned in Alexander Shulgin's 1997 book TiHKAL (Tryptamines I Have Known and Loved) and is not known to have been tested in humans.[5]

Interactions

See also: Psychedelic drug § Interactions, and Trip killer § Serotonergic psychedelic antidotes

Pharmacology

Pharmacodynamics

CPM-LAD showed affinity (Ki) values for serotonin receptors of 10.9 nM for serotonin-labeled 5-HT1 receptors and 7.7 nM for ketanserin-labeled 5-HT2 receptors.[1][2] These affinities were very similar to but slightly lower than those of LSD.[1][2] CPM-LAD fully substituted for LSD in rodent drug discrimination tests with an ED50Tooltip median effective dose of 0.067 μmol/kg, relative to a dose of 0.046 μmol/kg in the case of LSD (with CPM-LAD about 1.5-fold less potent than LSD).[1][2] Additional pharmacology for CPM-LAD has also been published.[4]

History

CPM-LAD was first described in the scientific literature by Andrew Joseph Hoffman of the lab of David E. Nichols at Purdue University in 1987.[3] Subsequently, it was patented by Gilgamesh Pharmaceuticals in 2022, who further studied and described its pharmacology.[4] Derivatives of CPM-LAD have also been patented by Daniel Trachsel and Matthias Liechti and colleagues in association with MindMed.[6]

Society and culture

Canada

CPM-LAD is not a controlled substance in Canada as of 2025.[7]

See also

References

External links

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