Cetraxate
Chemical compound
From Wikipedia, the free encyclopedia
Cetraxate (INN) is an oral gastrointestinal medication which has a cytoprotective effect.[1][2][unreliable medical source?]
ATC code
- none
Legal status
- In general: ℞ (Prescription only)
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Formula | C17H23NO4 |
| Molar mass | 305.374 g·mol−1 |
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Synthesis
Cetraxate is a prodrug of tranexamic acid. The latter is a hemostatic agent because it inhibits the activation of plasminogen to plasmin. The result is to prevent excess loss of blood in gastrointestinal ulcers. The synthesis begins with the esterification of 3-(p-hydroxyphenyl)propionic acid (2) by trans-4-cyanocyclohexanecarbonyl chloride (1). The product (3) is reduced to cetraxate (4) by catalytic hydrogenation with hydrogen and Raney nickel.[3][4]
