Crenezumab
From Wikipedia, the free encyclopedia
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | 1-40-β-amyloid |
| Clinical data | |
| ATC code |
|
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
|
| UNII | |
| KEGG | |
| Chemical and physical data | |
| Formula | C6442H9966N1706O2018S40 |
| Molar mass | 144884.91 g·mol−1 |
  (what is this?) (verify) | |
Crenezumab is a fully humanized monoclonal antibody against human 1-40 and 1-42 beta amyloid, which is being investigated as a treatment of Alzheimer's disease.[1] Crenezumab is highly homologous to solanezumab, another monoclonal antibody targeting amyloid-β peptides.[2] In June 2022, the US National Institutes of Health announced that the drug failed as a medication for early-onset Alzheimer's disease following the results of a decade-long clinical trial.[3]
Crenezumab was developed by Ruth Greferath, Ph.D., and Claude Nicolau, Ph.D., before the Swiss-based biopharmaceutical company AC Immune was founded, which focuses on developing targeted therapeutics for misfolded proteins that cause neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.[4] AC Immune was founded in 2003 by current CEO Andrea Pfeifer, Ph.D.[5] and funded primarily by German billionaire Dietmar Hopp.[6] In 2016, AC Immune filed for an IPO valuing the company at $700 million[7] and subsequently sold 6.9 million shares for net proceeds of $68.73 million.[8]
To develop crenezumab, AC Immune utilized its SupraAntigen technology, which involves injecting mice with liposomes that contain several hundred peptide mimics of antigens in order to generate a multitude of antibodies, from which the ones with best specificity are selected.[9] It is believed that crenezumab works by causing beta amyloid proteins to transition from an insoluble to a soluble form,[10] inhibiting aggregation and promoting disaggregation of existing plaques.[11]
Crenezumab was licensed to Genentech, Inc. in 2006.[12] Genentech is fully responsible for the clinical development, manufacturing, and commercialization of crenezumab.[11]