Dimdazenil
Chemical compound
From Wikipedia, the free encyclopedia
Dimdazenil, sold under the brand name Junoenil, is a medication used in the treatment of insomnia in China.[1] It is a benzodiazepine derivative and a partial positive allosteric modulator of the GABAA receptor[2] with two- to four-fold higher functional affinity for the α1 subunit relative to the α2, α3, and α5 subunits.
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| Trade names | Junoenil |
| Other names | EVT-201; EVT201 |
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| Formula | C17H17ClN6O2 |
| Molar mass | 372.81 g·mol−1 |
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Medical use
Dimdazenil shows effectiveness in the treatment of insomnia, but has less intrinsic activity in comparison to currently-marketed benzodiazepines and the Z-drugs;[3] however, it is thought that the lower efficacy may result in fewer side effects, such as motor incoordination.[3] In China, dimdazenil is approved for short-term treatment of insomnia.[4]
History
Dimdazenil was originally developed by Roche, based on preclinical data, as a non-sedating anxiolytic, but was found to produce sedation in humans in phase I clinical trials. For this reason, it was subsequently licensed to Evotec, which is now developing it for the treatment of insomnia.[3] By 2007, dimdazenil completed phase II clinical trials for this indication, with positive findings reported.[5] In China, the drug was developed by Zhejiang Jingxin Pharmaceutical.
