Draft:Bruno Botta
From Wikipedia, the free encyclopedia
Bruno Botta is a chemist and an academic. He is the rector of Unitelma Sapienza University of Rome.
Submission declined on 24 December 2025 by Ldm1954 (talk).
Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
|  |
Comment: Based upon his citations I do not view him as passing WP:NPROF.Being a rector does not count (established policy), and he does not have any very highly cited papers. If he had major peer awards that might tip him towards being notable. Ldm1954 (talk) 14:33, 24 December 2025 (UTC)
- Comment: In accordance with the Wikimedia Foundation's Terms of Use, I disclose that I have been paid by my employer for my contributions to this article. HRShami (talk) 05:12, 24 December 2025 (UTC)
Post-Doctoral degree
Unitelma Sapienza University of Rome
Bruno Botta | |
|---|---|
| Occupation | Chemist |
| Academic background | |
| Education | Master's degree Post-Doctoral degree |
| Alma mater | Sapienza University of Rome University of British Columbia |
| Academic work | |
| Institutions | Sapienza University of Rome Unitelma Sapienza University of Rome |
Education
Botta got his Master's degree in 1977 at the Sapienza University of Rome.[1] He was a postdoctoral associate in the Department of Chemistry of the University of British Columbia (UBC, Vancouver).[2]
Career
Botta was an assistant professor at the Catholic University of Rome from 1981 to 1992. Between 1992 and 2001, he was appointed as an associate professor of organic chemistry at the "Sapienza" University of Rome (Faculty of Pharmacy) and became a full professor in 2001. In 2023, he was appointed as the rector of Unitelma Sapienza University of Rome.[3] For the Italian publishing house Edi-Ermes, he has authored and edited two textbooks on organic chemistry.[4][5]
Research
Botta's research work has been centered on organic chemistry, with a particular focus on the fields of natural products chemistry and supramolecular chemistry. He has worked on prenylated flavonoids, specifically 8-prenyl naringenin, xanthumol, and artelastin, and has identified them as important cancer chemotherapeutic compounds.[6] He has also worked on synthetic organic chemistry,[7] with an emphasis on understanding of how reaction temperature controls exo/endo diastereoselectivity.[8] He has identified plants as a source of secondary metabolites,[9] screened 1,000 natural products from an in-house library, and documented that these metabolites possess antimicrobial and anticancer potential, which is regulated by autophagic mechanisms.[10] He has also highlighted alkaloids as a significant source of synthetic and semisynthetic compounds[11] and has focused on the synthesis and design of Hedgehog pathway inhibitors[12] based on isoflavone scaffold.[13] Furthermore, he has also identified ARNT inhibitors as antibiotic adjuvants.[14]
Botta chaired the COST Action CM1407, "Challenging Organic Syntheses Inspired by Nature – From Natural Products Chemistry to Drug Discovery".[15] Alongside COST Action, his research group has worked on natural products for their antimicrobial activity[16] as well as antibacterial, antiviral, and antineoplastic properties.[17] He has also studied the association between resorcin[4]arene V and pyrimidine nucleosides, providing insights into precise molecular recognition and the conceptualization of new medication carriers.[18] He has worked on "humanized chimeric Archaeal ferritin",[19] which significantly improved the effective and encapsulation delivery of siRNA.[20]
Selected articles
- Infante, Paola; Mori, Mattia; Alfonsi, Romina; Ghirga, Francesca; Aiello, Federica; Toscano, Sara; Ingallina, Cinzia; et al. (2015). "Gli1/ DNA Interaction is a Druggable Target for Hedgehog-Dependent Tumors". The EMBO Journal. 34 (2): 200–217. doi:10.15252/embj.201489213. PMC 4298015. PMID 25476449.
- Iovine, Valentina; Benni, Irene; Sabia, Rocchina; D’Acquarica, Ilaria; Fabrizi, Giancarlo; Botta, Bruno; Calcaterra, Andrea (2016). "Total Synthesis of (±)-Kuwanol E". Journal of Natural Products. 79 (10): 2495–2503. Bibcode:2016JNAtP..79.2495I. doi:10.1021/acs.jnatprod.6b00350. PMID 27656763.
- Ghirga, Francesca; Stefanelli, Roberta; Cavinato, Luca; Lo Sciuto, Alessandra; Corradi, Silvia; Quaglio, Deborah; Calcaterra, Andrea; et al. (2020). "A novel Colistin Adjuvant Identified by Virtual Screening for ArnT Inhibitors". Journal of Antimicrobial Chemotherapy. 75 (9): 2564–2572. doi:10.1093/jac/dkaa200. PMC 7443731. PMID 32514531.
- Quaglio, Deborah; Mangoni, Maria Luisa; Stefanelli, Roberta; Corradi, Silvia; Casciaro, Bruno; Vergine, Valeria; Lucantoni, Federica; et al. (2020). "ent -Beyerane Diterpenes as a Key Platform for the Development of ArnT-Mediated Colistin Resistance Inhibitors". The Journal of Organic Chemistry. 85 (16): 10891–10901. doi:10.1021/acs.joc.0c01459. PMID 32806095.
- Pediconi, Natalia; Ghirga, Francesca; Del Plato, Cristina; Peruzzi, Giovanna; Athanassopoulos, Constantinos M.; Mori, Mattia; et al. (2021). "Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells". Bioconjugate Chemistry. 32 (6): 1105–1116. doi:10.1021/acs.bioconjchem.1c00137. PMC 8253483. PMID 33978420.
- Calcaterra, Andrea; Polli, Francesca; Lamelza, Lara; Del Plato, Cristina; Cammarone, Silvia; Ghirga, Francesca; Botta, Bruno; Mazzei, Franco; Quaglio, Deborah (2023). "Resorc[4]arene-Modified Gold-Decorated Magnetic Nanoparticles for Immunosensor Development". Bioconjugate Chemistry. 34 (3): 529–537. doi:10.1021/acs.bioconjchem.2c00605. PMID 36753752.
- Quaglio, Deborah; Infante, Paola; Cammarone, Silvia; Lamelza, Lara; Conenna, Marilisa; Ghirga, Francesca; et al. (2023). "Exploring the Potential of Anthraquinone-Based Hybrids for Identifying a Novel Generation of Antagonists for the Smoothened Receptor in HH-Dependent Tumour". Chemistry – A European Journal. 29 (62) e202302237. doi:10.1002/chem.202302237. PMID 37565343.
- Nygaard, Rie; Graham, Chris L. B.; Belcher Dufrisne, Meagan; Colburn, Jonathan D.; Pepe, Joseph; Hydorn, Molly A.; et al. (2023). "Structural Basis of Peptidoglycan Synthesis by E. Coli RodA-PBP2 Complex". Nature Communications. 14 (1) 5151. Bibcode:2023NatCo..14.5151N. doi:10.1038/s41467-023-40483-8. PMID 37620344.
- Liberati, Francesca Romana; Di Russo, Sara; Barolo, Lorenzo; Peruzzi, Giovanna; Farina, Maria Vittoria; Spizzichino, Sharon; Di Fonzo, Federica; Quaglio, Deborah; Pisano, Luca; Botta, Bruno; et al. (2024). "Combined Delivery of miR-15/16 through Humanized Ferritin Nanocages for the Treatment of Chronic Lymphocytic Leukemia". Pharmaceutics. 16 (3): 402. doi:10.3390/pharmaceutics16030402. PMC 10974561. PMID 38543296.
- Falanga, Andrea Patrizia; Farina, Maria Vittoria; Cianfoni, Gabriele; Barolo, Lorenzo; Di Meo, Chiara; Borsatti, Giulia Elizabeth; Ghirga, Francesca; Botta, Bruno; et al. (2025). "Evaluation of Peptide Nucleic Acid Encapsulation in Ferritin Nanocages for Gene Silencing Applications". Biomacromolecules. 26 (11): 8040–8050. doi:10.1021/acs.biomac.5c01489. PMID 41134300.
or multiple published secondary sources that:
- provide significant coverage: discuss the subject in detail, not just brief mentions or routine announcements;
- are reliable: from reputable outlets with editorial oversight;
- are independent: not connected to the subject, such as interviews, press releases, the subject's own website, or sponsored content.
Please add references that meet these criteria. If none exist, the subject is not yet suitable for Wikipedia.