ERB-79

ERB-79 is a synthetic estrogen and a selective agonist of the ERβ.^[1][2][3] It is a racemic mixture, with the active enantiomer being ERB-26.^[2] ERB-79 shows more than 484-fold selectivity for transactivation of the ERβ over the ERα.^[1] Its EC₅₀ value for the ERβ is 0.448 nM (14.52% of the potency of estradiol) and for the ERα is 79 nM (0.03% of the potency of estradiol).^[1] It has no antagonistic activity at either receptor.^[1] ERB-79 is active in preclinical models of arthritis.^[1] The chemical structure of ERB-79 does not appear to have been disclosed.