ERH (gene)

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesERH, DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor

External IDsOMIM: 601191; MGI: 108089; HomoloGene: 3274; GeneCards: ERH; OMA:ERH - orthologs

Chr.Chromosome 14 (human)^[1]

Quick facts Available structures, PDB ...

ERH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W9G, 2NML
Identifiers
Aliases	ERH, DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor
External IDs	OMIM: 601191; MGI: 108089; HomoloGene: 3274; GeneCards: ERH; OMA:ERH - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q24.1 Start 69,380,128 bp[1] End 69,398,299 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 80,680,796 bp[2] End 80,691,115 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in seminal vesicula embryo ganglionic eminence ventricular zone Epithelium of choroid plexus lactiferous duct nasal epithelium renal medulla caput epididymis islet of Langerhans Top expressed in embryo yolk sac ventricular zone embryo tail of embryo morula blastocyst zygote genital tubercle neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyl-CpG binding protein binding RNA binding Cellular component methylosome midbody Biological process pyrimidine nucleoside metabolic process cell cycle nucleobase-containing compound metabolic process pyrimidine nucleotide biosynthetic process positive regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2079 13877 Ensembl ENSG00000100632 ENSMUSG00000021131 UniProt P84090 P84089 RefSeq (mRNA) NM_004450 NM_007951 NM_001347409 RefSeq (protein) NP_004441 NP_001334338 NP_031977 Location (UCSC) Chr 14: 69.38 – 69.4 Mb Chr 12: 80.68 – 80.69 Mb PubMed search [3] [4]
Wikidata
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SymbolER

PfamPF01133

InterProIPR000781

PROSITEPDOC00732

Quick facts Enhancer of rudimentary, Identifiers ...

Enhancer of rudimentary
crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
Symbol	ER
Pfam	PF01133
InterPro	IPR000781
PROSITE	PDOC00732
SCOP2	1j24 / SCOPe / SUPFAM
TCDB	3.A.16
Available protein structures: PDB   IPR000781 PF01133 (ECOD; PDBsum)   AlphaFold IPR000781 PF01133

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The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.^[8]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.^[6] It has been proposed that this protein plays a role in the cell cycle.