Eosinophil-derived neurotoxin

Eosinophil-derived neurotoxin is an enzyme that in humans is encoded by the RNASE2 gene.^[5][6][7]

AliasesRNASE2, EDN, RAF3, RNS2, ribonuclease A family member 2

External IDsOMIM: 131410; MGI: 1858598; GeneCards: RNASE2

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 14 (human)^[1]

Quick facts RNASE2, Identifiers ...

RNASE2
Identifiers
Aliases	RNASE2, EDN, RAF3, RNS2, ribonuclease A family member 2
External IDs	OMIM: 131410; MGI: 1858598; GeneCards: RNASE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GQV, 1HI2, 1HI3, 1HI4, 1HI5, 1K2A, 2BEX, 2BZZ, 2C01, 2C02, 2C05, 5E13
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 4.6.1.18 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,955,487 bp[1] End 20,956,436 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C1 Start 51,399,717 bp[2] End 51,400,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trabecular bone bone marrow bone marrow cell monocyte granulocyte blood right lung spleen germinal epithelium right adrenal cortex Top expressed in lip skin of external ear skin of abdomen esophagus skin of back gastrula cervix perirhinal cortex CA3 field entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nuclease activity endonuclease activity hydrolase activity ribonuclease A activity nucleic acid binding lipopolysaccharide binding ribonuclease activity lyase activity Cellular component extracellular region lysosome extracellular exosome azurophil granule lumen Biological process chemotaxis RNA catabolic process RNA phosphodiester bond hydrolysis, endonucleolytic positive regulation of protein targeting to mitochondrion neutrophil degranulation induction of bacterial agglutination defense response to Gram-negative bacterium defense response to Gram-positive bacterium RNA phosphodiester bond hydrolysis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6036 54159 Ensembl ENSG00000169385 ENSMUSG00000059606 UniProt P10153 O35292 RefSeq (mRNA) NM_002934 NM_019398 RefSeq (protein) NP_002925 NP_062271 Location (UCSC) Chr 14: 20.96 – 20.96 Mb Chr 14: 51.4 – 51.4 Mb PubMed search [3] [4]
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The protein encoded by this gene is found in eosinophil granulocytes. It is closely related to the eosinophil cationic protein (RNASE3) from which it diverged ~50 million years ago after the split between the old world and the new world monkeys.^[8] It is relatively neutral and has cytotoxic properties. It is capable of reducing the activity of single strand RNA viruses in culture through its enzymatic activity. It also serves as an attractant to immune cells.