FLVCR2
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| FLVCR2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | FLVCR2, C14orf58, CCT, EPV, FLVCRL14q, MFSD7C, PVHH, feline leukemia virus subgroup C cellular receptor family member 2, SLC49A2, FLVCR heme transporter 2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610865; MGI: 2384974; HomoloGene: 9840; GeneCards: FLVCR2; OMA:FLVCR2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Feline leukemia virus subgroup C cellular receptor family, member 2 (FLVCR2) is a choline transporter belonging to the major facilitator superfamily (MFS).[5] It is a uniporter transmembrane protein that transports choline across the plasma membrane via a concentration gradient. FLVCR2 is highly enriched in endothelial cells of the blood-brain barrier but is also expressed in peripheral tissues such as the small intestine where it absorbs dietary choline.[6][7][8] At the blood-brain barrier, FLVCR2 is the primary transporter of choline responsible for approximately 60% of the brains supply.[5]
Mutations in FLVCR2 have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (Fowler syndrome).[9]
In 2009, the feline FLVCR2 ortholog was the first identified as a receptor of the Feline leukemia virus (FeLV) in cats.[10] The following year, it was characterised as a heme transporter as it was shown to bind heme, increase heme transport.[11] However, in 2024 it was shown to transport choline both in vivo and in vitro through the use of radiolabel choline transport assays and structural characterisation showing choline bound.[5] FLVCR2's role in disease and interactions with heme remains an ongoing investigation.
