Fluoroestradiol (18F)

Fluoroestradiol F-18, also known as [¹⁸F]16α-fluoroestradiol and sold under the brand name Cerianna, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) imaging.^{[1][2][3][4][5]} It is an analog of estrogen and is used to detect estrogen receptor-positive breast cancer lesions.^[1]

Trade namesCerianna

Other names[¹⁸F]16α-Fluoroestradiol; [¹⁸F]16α-Fluoroestra-1,3,5(10)-triene-3,17β-diol

License data

• US DailyMed: Fluoroestradiol

Routes of
administrationIntravenous injection

Quick facts Clinical data, Trade names ...

Fluoroestradiol (¹⁸
F)

Clinical data
Trade names	Cerianna
Other names	[18F]16α-Fluoroestradiol; [18F]16α-Fluoroestra-1,3,5(10)-triene-3,17β-diol
License data	US DailyMed: Fluoroestradiol
Routes of administration	Intravenous injection
Drug class	Estrogen; Diagnostic radiopharmaceutical
ATC code	V09IX11 (WHO)
Legal status
Legal status	US: ℞-only[1]
Pharmacokinetic data
Metabolism	Liver[1]
Excretion	Gallbladder and kidney[1]
Identifiers
IUPAC name (8R,9S,13S,14S,16R,17R)-16-(18F)fluoranyl-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
CAS Number	94153-53-4
PubChem CID	10869981
ChemSpider	9045262
UNII	T32277KB09
KEGG	D11829
CompTox Dashboard (EPA)	DTXSID101027872
Chemical and physical data
Formula	C18H23[18F]O2
Molar mass	289.37 [1]
3D model (JSmol)	Interactive image
SMILES C[C@]12CC[C@@]3([H])[C@](CCC4=C3C=CC(O)=C4)([H])C1C[C@@H]([18F])[C@@H]2O
InChI InChI=1S/C18H23FO2/c1-18-7-6-13-12-5-3-11(20)8-10(12)2-4-14(13)15(18)9-16(19)17(18)21/h3,5,8,13-17,20-21H,2,4,6-7,9H2,1H3/t13-,14-,15+,16-,17+,18+/m1/s1/i19-1 Key:KDLLNMRYZGUVMA-ZYMZXAKXSA-N

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