Fluoroproscaline

Fluoroproscaline (FP), also known as 4-(3-fluoropropoxy)-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.^[1][2] It is a fluorinated derivative of proscaline.^[1][2][3] The drug has a dose range of 60 to 150 mg and a duration of 3 to 5 hours.^[1][2] It is less potent than proscaline but more potent than mescaline and is much shorter-acting than proscaline or mescaline.^[1][2] The receptor interactions of fluoroproscaline have been studied.^[4][1][2] It is a low-affinity and low-potency agonist of the serotonin 5-HT_2A receptor.^[4][1][2] The chemical synthesis of fluoroproscaline has been described.^[3] The drug was first described in the scientific literature by Daniel Trachsel in 2002.^[2][1][3] The pharmacology of fluoroproscaline was studied in greater detail in 2021.^[4] It is not a controlled substance in Canada as of 2025.^[5]

Other namesFP; 3-Fluoroproscaline; 3-FP; 4-(3-Fluoropropoxy)-3,5-dimethoxyphenethylamine

Routes of
administrationOral^[1][2]

Drug classSerotonin receptor modulator; Serotonin 5-HT_2A receptor agonist; Serotonergic psychedelic; Hallucinogen

ATC code

• None

Quick facts Clinical data, Other names ...

Fluoroproscaline

Clinical data
Other names	FP; 3-Fluoroproscaline; 3-FP; 4-(3-Fluoropropoxy)-3,5-dimethoxyphenethylamine
Routes of administration	Oral[1][2]
Drug class	Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code	None
Pharmacokinetic data
Duration of action	3–5 hours[1][2]
Identifiers
IUPAC name 2-[4-(3-fluoropropoxy)-3,5-dimethoxyphenyl]ethanamine
CAS Number	501700-04-5
PubChem CID	57478627
ChemSpider	36606254
Chemical and physical data
Formula	C13H20FNO3
Molar mass	257.305 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=CC(=CC(=C1OCCCF)OC)CCN
InChI InChI=1S/C13H20FNO3/c1-16-11-8-10(4-6-15)9-12(17-2)13(11)18-7-3-5-14/h8-9H,3-7,15H2,1-2H3 Key:FMAGEKSBHIYXPF-UHFFFAOYSA-N

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