Fluticasone

Fluticasone is a manufactured glucocorticoid used to treat nasal congestion.^{[1][2][3][4][5]} Both the esters, fluticasone propionate (sold as Flovent) and fluticasone furoate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.^[3][2][4][6]

Other names6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate

Routes of
administrationIntranasal, inhalation, topical

ATC code

• D07AC17 (WHO) R01AD08 (WHO) R03BA05 (WHO) R01AD58 (WHO)

Legal status

• CA: OTC

Quick facts Clinical data, Other names ...

Fluticasone

Clinical data
Other names	6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate
Routes of administration	Intranasal, inhalation, topical
ATC code	D07AC17 (WHO) R01AD08 (WHO) R03BA05 (WHO) R01AD58 (WHO)
Legal status
Legal status	CA: OTC
Pharmacokinetic data
Bioavailability	0.51% (Intranasal)
Protein binding	91.0%
Metabolism	Intranasal Liver (CYP3A4-mediated)
Elimination half-life	10 hours
Excretion	Kidney
Identifiers
IUPAC name S-fluoromethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carbothioate
CAS Number	90566-53-3 N
PubChem CID	5311101
IUPHAR/BPS	6699
DrugBank	DB00588 N
ChemSpider	4470631 Y
UNII	CUT2W21N7U
KEGG	D07981 Y
ChEBI	CHEBI:5134 N
ChEMBL	ChEMBL1201396 N
CompTox Dashboard (EPA)	DTXSID0044022
Chemical and physical data
Formula	C22H27F3O4S
Molar mass	444.51 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C
InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 Y Key:MGNNYOODZCAHBA-GQKYHHCASA-N Y
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Fluticasone is on the World Health Organization's List of Essential Medicines.^[7] In 2023, it was the 26th most commonly prescribed medication in the United States, with more than 21 million prescriptions,^[8][9] although it is also sold over-the-counter (OTC).^[10]