Alsace was developed as part of a joint Italian-French program known as FREMM, which was implemented to develop a new class of frigates for use by various European navies. Constructed from 2016. On 18 April 2019, the frigate Alsace was launched. She began sea trials in October 2020[13] and was delivered to French Navy in April 2021.[14] The ship was declared fully operational on 22 November 2021.[8]
From 18 November to 2 December 2021, Alsace took part in Exercise Polaris 21 in the western Mediterranean Sea.[15]
From January to May 2022, Alsace deployed as part of Clemenceau 22 led by the aircraft carrier Charles de Gaulle.[16] According to the ship's captain, Sébastien Baquer, while the Horizon-class frigate Forbin took on the lead air defence mission within the task group, Alsace performed the primary air defence mission as part of the task group "for significant periods" during the deployment. During other periods, Alsace carried out a primary anti-submarine mission. Speaking about how the frigate balances its air defence and ASW missions, Captain Baquer noted that: "a single unit cannot optimize its capabilities in both areas simultaneously, but they are not mutually exclusive. Thus, FREMM DA adapts its electro-acoustic policy to the maneuver idea of the commander of the Carrier Strike Group (CSG) and is able to change its priority domain at short notice".[17]
In October 2023 Alsace was deployed to the Eastern Mediterranean during the Gaza war, joining the helicopter assault ship Tonnerre and the frigate Surcouf which were also deployed to the region.[18] In January 2024, she transitted through the Suez Canal to join multi-national defence operations in the Red Sea in the face of Houthi attacks against international shipping.[19] On 21 March 2024, Alsace shot down three ballistic missiles coming from Yemen, likely using the Aster 30 missile.[20]
Alsace formed a part of the Carrier Strike Group (CSG) centred on Charles de Gaulle during the Mission Clemenceau 25 deployment that began on 28 November 2024.[21][22]
On 5 January, Alsace and Forbin arrived at Kochi Port. While the rest of the components of the CSG including Charles de Gaulle docked in Mormugao Port Trust Jetty, Goa, on 4 January 2025. The CSG remained in India until 9 January.[23][24][25]