GPR6

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

G protein-coupled receptor 6, also known as GPR6, is a protein which in humans is encoded by the GPR6 gene.[5][6]

AliasesGPR6, G protein-coupled receptor 6
End109,980,720 bp[1]
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GPR6
Identifiers
AliasesGPR6, G protein-coupled receptor 6
External IDsOMIM: 600553; MGI: 2155249; HomoloGene: 38026; GeneCards: GPR6; OMA:GPR6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005284
NM_001286099

NM_199058

RefSeq (protein)

NP_001273028
NP_005275

NP_951013

Location (UCSC)Chr 6: 109.98 – 109.98 MbChr 10: 40.95 – 40.95 Mb
PubMed search[3][4]
Wikidata
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Function

GPR6 is a member of the G protein-coupled receptor family of transmembrane receptors. It has been reported that GPR6 is both constitutively active but in addition is further activated by sphingosine-1-phosphate.[7]

GPR6 up-regulates cyclic AMP levels and promotes neurite outgrowth.[8]

Ligand

Inverse Agonist

Evolution

See also

References

Further reading

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