GR-55562

GR-55562 is a selective serotonin 5-HT_1B and 5-HT_1D receptor antagonist.^[1] It is one of several selective serotonin 5-HT_1B receptor antagonists used in scientific research.^[2][3]

Other namesGR55562; GR-55,562; GR55,562

Drug classSerotonin 5-HT_1B and 5-HT_1D receptor antagonist; Selective serotonin 5-HT_1B antagonist

CAS Number

• 159533-26-3

PubChem CID

• 128018

Quick facts Clinical data, Other names ...

GR-55562

Clinical data
Other names	GR55562; GR-55,562; GR55,562
Drug class	Serotonin 5-HT1B and 5-HT1D receptor antagonist; Selective serotonin 5-HT1B antagonist
Identifiers
IUPAC name 3-[3-(dimethylamino)propyl]-4-hydroxy-N-(4-pyridin-4-ylphenyl)benzamide
CAS Number	159533-26-3
PubChem CID	128018
IUPHAR/BPS	113
ChemSpider	113523
UNII	QPY74DMU5M
ChEBI	CHEBI:92813
ChEMBL	ChEMBL119264
CompTox Dashboard (EPA)	DTXSID701150576
Chemical and physical data
Formula	C23H25N3O2
Molar mass	375.472 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCCC1=C(C=CC(=C1)C(=O)NC2=CC=C(C=C2)C3=CC=NC=C3)O
InChI InChI=1S/C23H25N3O2/c1-26(2)15-3-4-19-16-20(7-10-22(19)27)23(28)25-21-8-5-17(6-9-21)18-11-13-24-14-12-18/h5-14,16,27H,3-4,15H2,1-2H3,(H,25,28) Key:ZAGAUUVCYGSPBP-UHFFFAOYSA-N

Close

The drug is a silent antagonist of the serotonin 5-HT_1B receptor, unlike the related agent GR-127935.^[1][4] GR-55562 has around 10-fold selectivity for the serotonin 5-HT_1B receptor over the serotonin 5-HT_1D receptor and has only weak affinity for a number of other serotonin receptors.^[4]

It is ineffective in attenuating MDMA-induced prosocial behavior in animals.^[5][6] Conversely, the serotonin 5-HT_1A receptor antagonist WAY-100635 can abolish MDMA-induced prosocial behavior.^[5][6]