GZMB

GZMB is a gene that in humans encodes the enzyme Granzyme B, a serine protease expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells.^[5]

AliasesGZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11

External IDsOMIM: 123910; MGI: 109267; GeneCards: GZMB

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 14 (human)^[1]

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GZMB
Identifiers
Aliases	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
External IDs	OMIM: 123910; MGI: 109267; GeneCards: GZMB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FQ3, 1IAU
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.4.21.79 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,630,954 bp[1] End 24,634,267 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C3|14 28.19 cM Start 56,496,295 bp[2] End 56,499,717 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood mononuclear cell monocyte spleen bone marrow decidua lymph node right lung appendix Top expressed in gastrula jejunum duodenum decidua blood intestinal villus embryo pharynx uterus seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity protein binding serine-type peptidase activity serine-type endopeptidase activity hydrolase activity Cellular component cytosol membrane immunological synapse nucleus mitochondrion secretory granule cytoplasm Biological process cytolysis proteolysis positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway natural killer cell mediated cytotoxicity apoptotic process granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3002 14939 Ensembl ENSG00000100453 ENSMUSG00000015437 UniProt P10144 P04187 RefSeq (mRNA) NM_004131 NM_001346011 NM_013542 RefSeq (protein) NP_001332940 NP_004122 NP_038570 Location (UCSC) Chr 14: 24.63 – 24.63 Mb Chr 14: 56.5 – 56.5 Mb PubMed search [3] [4]
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CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.^[6]