Ganfeborole

Ganfeborole
Identifiers
	IUPAC name 2-[[(3S)-3-(Aminomethyl)-4-chloro-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]ethanol;
CAS Number	2131798-12-2;
PubChem CID	133080621;
ChemSpider	71046056;
UNII	KZ8H57WFC7;
ChEMBL	ChEMBL4116378;
Chemical and physical data
Formula	C10H13BClNO4
Molar mass	257.48 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES B1(C2=C(C=CC(=C2[C@H](O1)CN)Cl)OCCO)O(C(=O)N1)CCN)CCN)CC(C)C)CC2=CC=CC=C2)CCN)NC(=O)[C@@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)C)O;
	InChI InChI=1S/C10H13BClNO4/c12-6-1-2-7(16-4-3-14)10-9(6)8(5-13)17-11(10)15/h1-2,8,14-15H,3-5,13H2/t8-/m1/s1; Key:DJUOWOXTPXUHDQ-MRVPVSSYSA-N;

Ganfeborole (GSK3036656, GSK-070) is an experimental antibiotic which shows activity against Mycobacterium tuberculosis. It acts as a potent and selective inhibitor of the bacterial leucyl-tRNA synthetase enzyme, and is currently in clinical trials.^[1]^[2]^[3]

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Identifiers

IUPAC name 2-[[(3S)-3-(Aminomethyl)-4-chloro-1-hydroxy-3H-2,1-benzoxaborol-7-yl]oxy]ethanol
CAS Number	2131798-12-2
PubChem CID	133080621
ChemSpider	71046056
UNII	KZ8H57WFC7
ChEMBL	ChEMBL4116378
Chemical and physical data
Formula	C₁₀H₁₃BClNO₄
Molar mass	257.48 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES B1(C2=C(C=CC(=C2[C@H](O1)CN)Cl)OCCO)O(C(=O)N1)CCN)CCN)CC(C)C)CC2=CC=CC=C2)CCN)NC(=O)[C@@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)C)O
InChI InChI=1S/C10H13BClNO4/c12-6-1-2-7(16-4-3-14)10-9(6)8(5-13)17-11(10)15/h1-2,8,14-15H,3-5,13H2/t8-/m1/s1 Key:DJUOWOXTPXUHDQ-MRVPVSSYSA-N