Govorestat

Govorestat (AT-007) is an aldose reductase inhibitor and experimental drug to treat galactosemia^[1] and sorbitol dehydrogenase deficiency.^[2]

Other namesAT-007

ATC code

• A16AX24 (WHO)

CAS Number

• 2170729-29-8

PubChem CID

• 132260161

Quick facts Clinical data, Other names ...

Govorestat

Clinical data
Other names	AT-007
ATC code	A16AX24 (WHO)
Identifiers
IUPAC name 2-[4-Oxo-3-[[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl]thieno[3,4-d]pyridazin-1-yl]acetic acid
CAS Number	2170729-29-8
PubChem CID	132260161
DrugBank	DB16707
ChemSpider	81409264
UNII	6JLQ8K35KK
ChEMBL	ChEMBL4650327
Chemical and physical data
Formula	C17H10F3N3O3S2
Molar mass	425.40 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC2=C(C=C1C(F)(F)F)N=C(S2)CN3C(=O)C4=CSC=C4C(=N3)CC(=O)O
InChI InChI=1S/C17H10F3N3O3S2/c18-17(19,20)8-1-2-13-12(3-8)21-14(28-13)5-23-16(26)10-7-27-6-9(10)11(22-23)4-15(24)25/h1-3,6-7H,4-5H2,(H,24,25) Key:ORQGHAJIWGGFJK-UHFFFAOYSA-N

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After a report circulating on the internet accused the developer Applied Therapeutics of cutting corners in its studies of the drug, the FDA put a hold on it in 2020. Applied Therapeutics said that the report was a fraudulent attempt to manipulate its stock price.^[3]

In February 2024, the FDA granted priority review states to an application from Applied Therapeutics to use govorestat to treat galactosemia, a metabolic disease.^[4] The FDA then rejected the company’s application in November 2024, and issued a warning letter to then-President Shoshana Shendelman informing her of “objectionable conditions” observed during an FDA inspection earlier that year.^[5]