HLA-B44

Human leukocyte antigen serotype From Wikipedia, the free encyclopedia

HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.[1]

Illustration of HLA-B with peptide in the binding pocket.
HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B44
Alleles B*4401, 4402, 4403 . .
Structure (See HLA-B)
Shared data
Locus chr.6 6p21.31

B44 is a split antigen of the broad antigen B12, and is a sister type of B45.

Serotype

Serotypes B44, B12, and B45 recognition of the
HLA B*44 gene products[2]
B*44B44 B12 B45Sample
allele%%%size (N)
*4402986959
*4403942854
*44046542
*440592130
*4406449
B*4401 was shown to be B*4402 after errors corrected.
Alleles link-out to IMGT/HLA Database at EBI

Alleles

Disease

HLA-B44 increases recurrent sinopulmonary infections.[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).[4] B44 may be a cofactor in ankylosing spondylitis[5]

References

Related Articles

Wikiwand AI