HLA-DR12
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HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens.
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major histocompatibility complex, class II, DR12 | |
| Haplotypes groups | DQA*01:DRB1*1201 to DQA*01:DRB1*1203 DQA*01:DRB1*1206 |
| Structure (See HLA-DR) | |
| Identifiers | alpha *0101 |
| Symbol(s) | HLA-DRA[permanent dead link] |
| EBI-HLA | DRA*0101 |
| Identifiers | beta 1 *1201 to *1203 *1206 |
| Symbol(s) | HLA-DRB1[permanent dead link] |
| EBI-HLA | DRB1*1201 |
| EBI-HLA | DRB1*1202 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1203 Archived 2011-05-15 at the Wayback Machine |
| EBI-HLA | DRB1*1306 |
| Shared data | |
| Locus | chr.6 6p21.31 |
Serology
| DRB1* | DR12 | DR5 | DR11 | Sample |
| allele | % | % | % | size (N) |
| 1201 | 83 | 4 | 2 | 893 [2] |
| 1202 | 89 | 162 | ||
| 1203 | >50 | 3 | ||
| 1206 | >50 | 2 | ||
The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215
Alleles
There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific.
Disease associations
DR12 is associated with vulval lichen sclerosus,[3] and undifferentiated spondyloarthritis.[4]
DRB1*1201 is associated with iritis in juvenile arthritis,[5] primary antiphospholipid syndrome,[6] tiopronin intolerance in rheumatoid arthritis,[7] adult chronic articular Still's disease[8]
DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population,[9] and narcolepsy in the Japanese population.
Extended linkage
DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a transhaplotype risk for coeliac disease[10]
DRB1*1201:DRB3*01/03: colorectal cancer[11]
Genetic Linkage
DR12 Haplotypes | ||||
| Serotypes | DRA | DRB1 | DRB3 | |
|---|---|---|---|---|
| DR11(5)-DR52 | *0101 | *1201 | *0101 | |
| *0101 | *1202 | *0201 | ||
| *0101 | *1202 | *0202 | ||
| *0101 | *1202 | *0301 | ||
| Serotypes | DRB1 | DQA1 | DQB1 | |
| DR12(5)-DQ7 (7.5, 3) | *1201 | *0505 | *0301 | |
| *1202 | *0505 | *0301 | ||
| DR12(5)-DQ7 (7.3, 3) | *1201 | *0303 | *0301 | |
| DR12(5)-DQ7 (7.4, 3) | *1201 | *0401 | *0301 | |
| DR12(5)-DQ7 (7.6, 3) | *1201 | *0601 | *0301 | |
| Serotypes | HLA-A | HLA-C | HLA-B | DRB1 |
| A31(19)-Cw10-B51(5)-DR12(5) | *3101 | *0304 | *5101 | *1202 |
| A11-Cw9-B75(15)-DR12(5) | *1101 | *0303 | *1502 | *1202 |
| A2-Cw10-B13-DR12(5) | *0201 | *0304 | *1301 | *1202 |
HLA-DR12 is genetically linked to DR52[12] and HLA-DQ7 serotypes.