Halloween on Spooner Street

Peter and Joe target Quagmire for this year's Halloween pranks, including bombarding him with eggs, Joe dressing up as a girl and sleeping with him, and infecting him with an unknown disease carried by a mosquito from Senegal. Afterwards, Peter praises Quagmire for being a good sport and the two decide to go drinking. Deciding to approach Joe, they convince him to allow them to follow him in his police car. Agreeing to do so only if they stay in his car, Peter and Quagmire soon become a nuisance. Ultimately, they drive to an old airfield where they discover a Mitsubishi Zero, a Japanese fighter plane used during World War II. Quagmire flies the two into the sky and pretending to have Japanese heritage and the urge to do kamikaze he eventually takes them on a high speed dive into the ocean near Quahog Harbor, stopping only inches from crashing stating that it was payback for making him have sex with Joe.

Meanwhile, Stewie discovers trick-or-treaters (at first thinking they are real monsters and shooting at them with an M16), and soon wants to partake in the activity. Deciding to dress as a baby duck, he is subsequently bullied by a gang of three older boys who steal his candy. Searching for Brian, Stewie blames him for causing him to lose his candy and convinces him to steal back the candy from the bullies. Approaching the bullies to get the candy back, Brian is immediately painted pink. Seeking revenge, Stewie half jokingly suggests to Brian that they kill the bullies, though they both agree they can't actually do that. When his plan to threaten them with a bazooka fails (and ends up killing a Godzilla-like monster instead), Stewie goes to "Plan B" and begins crying for his mother. Lois then confronts the lead bully Justin's mother and becomes her bully instead, demanding Stewie's candy back, demanding Justin's candy, and $40. But because she does not have any money, Lois takes their welcome mat and says she'll be back tomorrow for $80.

The same night, Meg decides to go trick-or-treating with her friends and attends a party held at Connie D'Amico's house. Excited no one can see through her slutty cat costume (even her father, Peter, who says "Ugly bitches!" to her and her friends), Meg eventually wins at spin the bottle; she unknowingly begins making out in a dark closet with her brother Chris, who is wearing an Optimus Prime costume that conceals his identity. When Connie opens the closet, the siblings are in their underwear, and immediately horrified at the revelation.

During the credits, Stewie and Brian reminiscing of the night and sorting their candy just as Meg and Chris come home. Meg and Chris both make light of the situation by convincing each other that they successfully hooked up with a hot date. Meg states that her date might even call back, but Chris immediately says that she might be disappointed, even though she was most likely just playing along.

The episode was written by series regular Andrew Goldberg and directed by series regular Jerry Langford before the conclusion of the ninth production season. Series veterans Peter Shin and James Purdum, both of whom having previously served as animation directors, served as supervising directors for the episode, with episode writer Goldberg, along with Alex Carter, Elaine Ko, Spencer Porter and Aaron Blitzstein serving as staff writers for the episode. Composer Walter Murphy, who has worked on the series since its inception, returned to compose the music for "Halloween on Spooner Street". The episode was the first Halloween special to be produced for the series.

In addition to the regular cast, the episode featured guest performances by actors James Burkholder, Noah Matthews, Lyndon Smith, Patrick Stewart, Nana Visitor, and Lisa Wilhoit, voice actors Chris Cox and Barclay DeVeau, and performer and actress Christina Milian. Recurring guest voice actors John G. Brennan, writers Danny Smith, Alec Sulkin, and John Viener, and actor Ralph Garman, made minor appearances. Adam West made a guest appearance as well.

Chris dresses up as Bill Cosby for Halloween, but Lois insists that he change his costume because he is wearing blackface. He reluctantly changes his Halloween costume and dresses up as Optimus Prime. When Quagmire talks about him being half-Japanese, Peter confuses "kamikaze" with "Karma Chameleon", the 1983 Culture Club song. The Pink Panther makes another appearance in the show, when he asks Brian if it is his first day being pink. Brian says "yes", to which Pink Panther replies "Welcome to hell." When Stewie climbs on top of the shed to threaten the bullies who stole his candy, he shouts "hello" while pointing a rocket launcher at them, which is a reference to Raiders of the Lost Ark. When Joe, Peter and Quagmire fly off in a Japanese Zero, an Asian version of the theme from Top Gun plays.