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IHCH-7179

Pharmaceutical compound From Wikipedia, the free encyclopedia

IHCH-7179 is a serotonin and dopamine receptor modulator related to the ergolines and phenylpiperazines.[1][2] It acts as a serotonin 5-HT1A receptor agonist, serotonin 5-HT2A receptor antagonist, and dopamine D2 receptor partial agonist.[1] The drug produces antipsychotic-like effects in rodents, such as prevention of the hyperlocomotion induced by the NMDA receptor antagonist dizocilpine (MK-801).[1] It also blocks the head-twitch response induced by the serotonergic psychedelic LSD.[1] IHCH-7179 was first described in the scientific literature by 2024.[1] It was developed by the Chinese Academy of Sciences and associated organizations in Shanghai, China.[1][2] IHCH-7179 is of interest for potential treatment of schizophrenia.[1][2]

Other namesIHCH7179
ATC code
  • None
Quick facts Clinical data, Other names ...
IHCH-7179
Clinical data
Other namesIHCH7179
Drug classSerotonin 5-HT1A receptor agonist; Serotonin 5-HT2A receptor antagonist; Dopamine D2 receptor partial agonist
ATC code
  • None
Identifiers
  • 1-(4-fluorophenyl)-4-(2,5,11-triazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl)butan-1-one
CAS Number
PubChem CID
PDB ligand
Chemical and physical data
FormulaC23H24FN3O
Molar mass377.463 g·mol−1
3D model (JSmol)
  • C1CN2C(CC3=CNC4=C3C2=CC=C4)CN1CCCC(=O)C5=CC=C(C=C5)F
  • InChI=1S/C23H24FN3O/c24-18-8-6-16(7-9-18)22(28)5-2-10-26-11-12-27-19(15-26)13-17-14-25-20-3-1-4-21(27)23(17)20/h1,3-4,6-9,14,19,25H,2,5,10-13,15H2
  • Key:QNGJKKMQTDOCDJ-UHFFFAOYSA-N
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