Interleukin 10 receptor, beta subunit

Interleukin 10 receptor, beta subunit is a subunit for the interleukin-10 receptor. IL10RB is its human gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesIL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, Interleukin 10 receptor, beta subunit, interleukin 10 receptor subunit beta

External IDsOMIM: 123889; MGI: 109380; HomoloGene: 523; GeneCards: IL10RB; OMA:IL10RB - orthologs

Chr.Chromosome 21 (human)^[1]

Quick facts IL10RB, Available structures ...

IL10RB
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LQM
Identifiers
Aliases	IL10RB, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IL-10R2, Interleukin 10 receptor, beta subunit, interleukin 10 receptor subunit beta
External IDs	OMIM: 123889; MGI: 109380; HomoloGene: 523; GeneCards: IL10RB; OMA:IL10RB - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.11 Start 33,266,367 bp[1] End 33,310,187 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 52.87 cM Start 91,203,052 bp[2] End 91,222,722 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta monocyte blood granulocyte mucosa of transverse colon rectum spleen duodenum appendix gallbladder Top expressed in Ileal epithelium adrenal gland cardiac muscle tissue of left ventricle stroma of bone marrow interventricular septum right ventricle granulocyte right lung lobe choroid plexus of fourth ventricle lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding interleukin-10 receptor activity signaling receptor activity cytokine receptor activity Cellular component integral component of membrane interleukin-28 receptor complex membrane plasma membrane Biological process inflammatory response defense response to virus immune response signal transduction cytokine-mediated signaling pathway positive regulation of receptor signaling pathway via JAK-STAT Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3588 16155 Ensembl ENSG00000243646 ENSMUSG00000022969 UniProt Q08334 Q61190 RefSeq (mRNA) NM_000628 NM_008349 RefSeq (protein) NP_000619 n/a Location (UCSC) Chr 21: 33.27 – 33.31 Mb Chr 16: 91.2 – 91.22 Mb PubMed search [3] [4]
Wikidata
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IL10RB has also been designated CDw210b (cluster of differentiation w210b).

The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFNAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.^[5]