INF2

INF2
Identifiers
Aliases	INF2, C14orf151, C14orf173, CMTDIE, FSGS5, pp9484, inverted formin, FH2 and WH2 domain containing, inverted formin 2
External IDs	OMIM: 610982; MGI: 1917685; HomoloGene: 82406; GeneCards: INF2; OMA:INF2 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	104,722,535 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	112,615,557 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; C1 segment; ; mucosa of transverse colon; ; right coronary artery; ; gastric mucosa; ; left coronary artery; ; popliteal artery; ; tibial arteries; ; putamen; ; right frontal lobe;
	Top expressed in
	gastrula; ; superior frontal gyrus; ; olfactory tubercle; ; decidua; ; nucleus accumbens; ; stroma of bone marrow; ; primary visual cortex; ; epithelium of lens; ; transitional epithelium of urinary bladder; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm;
Biological process	regulation of mitochondrial fission; actin cytoskeleton organization; cellular component organization;
	Sources:Amigo / QuickGO
Orthologs
	64423
	70435
	ENSG00000203485
	ENSMUSG00000037679
	Q27J81
	Q0GNC1
	NM_001031714; NM_022489; NM_032714
	NM_198411
	NP_001026884; NP_071934; NP_116103
	NP_940803; NP_001361128
	Wikidata
View/Edit Human	View/Edit Mouse

Inverted formin-2 is a protein that in humans is encoded by the INF2 gene.^[5]^[6] It belongs to the protein family called the formins. It has two splice isoforms, CAAX which localizes to the endoplasmic reticulum and non-CAAX which localizes to focal adhesions and the cytoplasm with enrichment at the Golgi.^[7]^[8] INF2 plays a role in mitochondrial fission and dorsal stress fiber formation.^[9] INF2 accelerates actin nucleation and elongation by interacting with barbed ends (fast-growing ends) of actin filaments, but also accelerates disassembly of actin through encircling and severing filaments.^[10]