IRF1

Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified. Initially described as a transcription factor able to activate expression of the cytokine Interferon beta,^[6] IRF-1 was subsequently shown to function as a transcriptional activator or repressor of a variety of target genes. IRF-1 regulates expression of target genes by binding to an interferon stimulated response element (ISRE) in their promoters. The IRF-1 protein binds to the ISRE via an N-terminal helix-turn-helix DNA binding domain,^[7] which is highly conserved among all IRF proteins.

Beyond its function as a transcription factor, IRF-1 has also been shown to trans-activate the tumour suppressor protein p53 through the recruitment of its co-factor p300.^[8]

IRF-1 has been shown to play roles in the immune response, regulating apoptosis, DNA damage and tumor suppression.^[9]

It has been shown that the extreme C-terminus of IRF-1 regulates its ability to activate transcription, nanobodies targeting this domain (MF1) are able to increase IRF-1 activity.^[10]

IRF1 has been shown to interact with:

• CHIP^[11]
• GAGE^[12]
• HSP70 / HSP90^[13]
• IRF8^[14][15]
• KPNA2^[16]
• MYD88^[17]
• PCAF^[18]
• STAT1^[19]
• TAT^[20]
• VEGFR2^[21]
• REDD2^[22]

• IRF2
• Interferon regulatory factors