IWS1

Protein IWS1 homolog also known as interacts with Spt6 (IWS1) is a protein that in humans is encoded by the IWS1 gene.^[5]

AliasesIWS1, SUPT6H interacting protein, interacts with SUPT6H, CTD assembly factor 1

External IDsMGI: 1920723; HomoloGene: 134421; GeneCards: IWS1; OMA:IWS1 - orthologs

Chr.Chromosome 2 (human)^[1]

End127,526,886 bp^[1]

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IWS1
Identifiers
Aliases	IWS1, SUPT6H interacting protein, interacts with SUPT6H, CTD assembly factor 1
External IDs	MGI: 1920723; HomoloGene: 134421; GeneCards: IWS1; OMA:IWS1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,436,207 bp[1] End 127,526,886 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 32,200,794 bp[2] End 32,237,381 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle mucosa of ileum Achilles tendon tendon of biceps brachii gastrocnemius muscle gonad right auricle of heart sural nerve left ventricle apex of heart Top expressed in tail of embryo hand otolith organ utricle genital tubercle superior cervical ganglion zygote trigeminal ganglion spermatocyte spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated mRNA transport RNA splicing regulation of histone H4 acetylation regulation of mRNA processing mRNA processing regulation of mRNA export from nucleus regulation of histone H3-K36 trimethylation transcription, DNA-templated transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter regulation of DNA-templated transcription, elongation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55677 73473 Ensembl ENSG00000163166 ENSMUSG00000024384 UniProt Q96ST2 Q8C1D8 RefSeq (mRNA) NM_017969 NM_173441 RefSeq (protein) NP_060439 NP_775617 Location (UCSC) Chr 2: 127.44 – 127.53 Mb Chr 18: 32.2 – 32.24 Mb PubMed search [3] [4]
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IWS1 is a transcription elongation factor. It was first identified during a search for RNA polymerase II-associated elongation factors in yeast; it directly interacts with RNA polymerase II (RNAPII) and is phosphorylated at casein kinase II (CKII) sites.^[6]

The human homolog, which physically interacts with protein arginine methyltransferase 5 (PRMT5), is essential for cell survival.^[7] It also recruits a SET2 histone methyltransferase (Huntingtin-interacting protein HYPB, also known as SETD2) to RNAPII during transcription elongation and is required for H3K36 trimethylation.^[8]